PMID- 8882968
OWN - NLM
STAT- MEDLINE
DCOM- 19970123
LR  - 20190116
IS  - 1042-8194 (Print)
IS  - 1026-8022 (Linking)
VI  - 22
IP  - 5-6
DP  - 1996 Aug
TI  - Adult T-cell leukemia (ATL) with an unusual immunophenotype and a high cellular 
      proliferation rate.
PG  - 523-6
AB  - A patient with adult T-cell leukemia (ATL) characterized by a suppressor 
      phenotype is reported. A 52-year-old mulatto male presented with symptoms and 
      signs of hypercalcemia. His laboratory finding disclosed a peripheral blood 
      specimen with abnormal cells characterized by a rather pleomorphic morphology and 
      polylobated nucleous typical of ATL cells. Serum calcium and LDH were 18.2 mg/dl 
      and 1373 IU, respectively. The phenotype of these cells was CD2+, CD4-, CD8+, 
      CD28+ associated with the expression of activated antigens such as CD25, CD38, 
      CD71 and CD30. Ki-67 positive were found in 20% of cells. The argyrophilic stain 
      for nuclear organizer regions (AgNORs) was shown one cluster in 35% of abnormal 
      cells. The serum antibodies were positive against human T-cell lymphotropic virus 
      type I (HTLV-I) and clinical features were compatible with the diagnosis of ATL 
      acute type. The combination therapy with cyclophosphamide, vincristine, 
      prednisone decreased the number of leukemic cells but the clinical course was 
      aggressive. He only responded transiently to treatment and died of multiorgan 
      failure due to uncontrollable septicemia two weeks after admission.
FAU - Lorand-Metze, I
AU  - Lorand-Metze I
AD  - Department of Internal Medicine, Faculty of Medicine of State University of 
      Campinas- Sao Paulo, Brazil.
FAU - Pombo-de-Oliveira, M S
AU  - Pombo-de-Oliveira MS
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (Antigens, CD)
SB  - IM
MH  - Adult
MH  - Antigens, CD/*blood
MH  - Bone Marrow/immunology/pathology
MH  - CD4-CD8 Ratio
MH  - Humans
MH  - Immunophenotyping
MH  - Lymphocytes/*immunology/pathology
MH  - Male
MH  - Middle Aged
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/blood/*immunology/pathology
EDAT- 1996/08/01 00:00
MHDA- 1996/08/01 00:01
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 1996/08/01 00:01 [medline]
PHST- 1996/08/01 00:00 [entrez]
AID - 10.3109/10428199609054793 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 1996 Aug;22(5-6):523-6. doi: 10.3109/10428199609054793.