PMID- 8883471
OWN - NLM
STAT- MEDLINE
DCOM- 19961127
LR  - 20190830
IS  - 0278-6915 (Print)
IS  - 0278-6915 (Linking)
VI  - 34
IP  - 8
DP  - 1996 Aug
TI  - Developmental toxicity of concanavalin A in rats: association with restricted 
      migration of neural crest cells.
PG  - 701-8
AB  - Concanavalin A (Con A), a plant lectin, was injected iv into pregnant rats as a 
      single dose of 5, 10 or 20 mg/kg on gestational day (GD) 8, to investigate 
      developmental toxicity in foetuses at term and to examine histologically embryos 
      between GD 10 and 12. There were high incidences of various malformations in the 
      10 and 20 mg/kg groups: externally, craniofacial dysplasia and closure defects of 
      the ventral body wall; internally, anophthalmia and cardiovascular malformations; 
      and in the skeleton, anomalies of the anterior region of the vertebrae and ribs. 
      Histological examination revealed that neural crest cells (NCC) in the control 
      embryos appeared to be streaming from the neural crest towards the ventral region 
      on GD 10, 11 and 12, and reached the region of the branchial arches on GD 12. By 
      contrast, those in the Con A-treated embryos were aggregated near the dorsal 
      region on GD 10 and 11, and had not reached the destination even on GD 12. These 
      findings suggest that pathogenesis of developmental toxicity of Con A in rats is 
      associated with disturbance of NCC migration and inhibition of their 
      pluripotentiality at the destination.
FAU - Nishida, A
AU  - Nishida A
AD  - Safety Research Laboratory, Tanabe Seiyaku Co Ltd, Osaka, Japan.
FAU - Kobayashi, T
AU  - Kobayashi T
FAU - Ariyuki, F
AU  - Ariyuki F
LA  - eng
PT  - Journal Article
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 11028-71-0 (Concanavalin A)
SB  - IM
MH  - *Abnormalities, Drug-Induced
MH  - Analysis of Variance
MH  - Animals
MH  - Body Weight/drug effects
MH  - Bone and Bones/abnormalities/drug effects
MH  - Brain/drug effects/pathology
MH  - Cell Movement/drug effects
MH  - Concanavalin A/*toxicity
MH  - Craniofacial Abnormalities/chemically induced
MH  - Embryonic and Fetal Development/*drug effects
MH  - Female
MH  - Gestational Age
MH  - Heart Defects, Congenital/chemically induced
MH  - Male
MH  - Neural Crest/cytology/*drug effects
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 1996/08/01 00:00
MHDA- 1996/08/01 00:01
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 1996/08/01 00:01 [medline]
PHST- 1996/08/01 00:00 [entrez]
AID - 0278691596000373 [pii]
AID - 10.1016/0278-6915(96)00037-3 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 1996 Aug;34(8):701-8. doi: 10.1016/0278-6915(96)00037-3.