PMID- 8884982
OWN - NLM
STAT- MEDLINE
DCOM- 19970512
LR  - 20190830
IS  - 0167-0115 (Print)
IS  - 0167-0115 (Linking)
VI  - 65
IP  - 2
DP  - 1996 Sep 9
TI  - Inhibitory effect of neuropeptide Y on growth hormone secretion in rats is 
      mediated by both Y1- and Y2-receptor subtypes and abolished after anterolateral 
      deafferentation of the medial basal hypothalamus.
PG  - 145-51
AB  - Neuropeptide Y (NPY) may play a physiological role in the regulation of growth 
      hormone (GH) secretion by acting via somatostatin (SS) in the periventricular 
      nucleus (PeV), as well as via the GH-releasing factor in the arcuate nucleus 
      (ARC) of the medial basal hypothalamus (MBH). The objectives of the present study 
      were to determine the neuron structures and receptor subtypes necessary for 
      mediating the inhibitory effect of NPY on GH secretion in unanesthetized male 
      rats. To eliminate the influence of hypophyseotropic SS, anterolateral 
      deafferentation (ALC) of the hypothalamus was performed. Intracerebroventricular 
      (i.c.v.) administration of 1.17 nmol of NPY decreased the blood level of GH for 
      3-4 h in sham-operated rats, while the procedure was without effect in ALC rats. 
      The i.c.v. administration of 1.17 nmol of a Y1-receptor agonist ([Leu31, 
      Pro34]-NPY) or a Y2-receptor agonist (NPY 13-36 and NPY 3-36) similarly 
      suppressed the blood GH level. The data support the hypothesis that neuron 
      structures anterolateral to the MBH are required for NPY-induced inhibition of GH 
      secretion that is mediated via Y1- and Y2-receptor subtypes. Combined with data 
      of other investigators, SS is likely the neurohumoral mediator of the effect of 
      NPY on GH secretion.
FAU - Suzuki, N
AU  - Suzuki N
AD  - Department of Medicine, Nippon Medical School, Tokyo, Japan.
FAU - Okada, K
AU  - Okada K
FAU - Minami, S
AU  - Minami S
FAU - Wakabayashi, I
AU  - Wakabayashi I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Regul Pept
JT  - Regulatory peptides
JID - 8100479
RN  - 0 (Neuropeptide Y)
RN  - 0 (Receptors, Neuropeptide Y)
RN  - 0 (neuropeptide Y-Y1 receptor)
RN  - 0 (neuropeptide Y2 receptor)
RN  - 125580-28-1 (neuropeptide Y, Leu(31)-Pro(34)-)
RN  - 9002-72-6 (Growth Hormone)
SB  - IM
MH  - Afferent Pathways/physiology
MH  - Animals
MH  - Growth Hormone/*metabolism
MH  - Humans
MH  - Hypothalamus, Middle/*physiology
MH  - Injections, Intraventricular
MH  - Male
MH  - Neuropeptide Y/administration & dosage/analogs & 
      derivatives/metabolism/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Neuropeptide Y/*metabolism
EDAT- 1996/09/09 00:00
MHDA- 1996/09/09 00:01
CRDT- 1996/09/09 00:00
PHST- 1996/09/09 00:00 [pubmed]
PHST- 1996/09/09 00:01 [medline]
PHST- 1996/09/09 00:00 [entrez]
AID - 0167-0115(96)00085-7 [pii]
AID - 10.1016/0167-0115(96)00085-7 [doi]
PST - ppublish
SO  - Regul Pept. 1996 Sep 9;65(2):145-51. doi: 10.1016/0167-0115(96)00085-7.