PMID- 8886585
OWN - NLM
STAT- MEDLINE
DCOM- 19970116
LR  - 20200304
IS  - 0012-4486 (Print)
IS  - 0012-4486 (Linking)
VI  - 91
IP  - 3
DP  - 1995-1996
TI  - Risk factors for choroidal neovascularization in young patients: a case-control 
      study.
PG  - 207-22
AB  - A pair-matched, case-control design was used to study exposure to Histoplasma 
      capsulatum and other environmental factors, and to determine various host 
      characteristics including human leukocyte antigen (HLA) typings in 94 young 
      patients with macular choroidal neovascularization (CNV) and in 94 controls with 
      other eye diseases. Patients with two types of retinal patterns were studied: 
      Type I, or those with CNV with one or no chorioretinal atrophic spots in the 
      posterior pole or periphery (n = 51), and Type II, or those with CNV and 2 or 
      more chorioretinal atrophic spots (n = 43). Our purpose was to explore whether 
      these two variants of idiopathic CNV have different and distinguishable 
      epidemiologies which may or may not be related to prior exposure to Histoplasma. 
      We found that histoplasmin skin tests were negative in all but two Type I cases. 
      The combination of the HLA-B7 and HLA-DR2 markers (but not either marker alone) 
      was significantly increased in Type I cases. Among Type II cases, HLA-B7, 
      HLA-DR2, HLA-DQ1, a positive histoplasmin skin test, myopic refractive error, 
      prior residence in a histoplasmosis endemic area, occupations involving exposure 
      to animals, and hypertension were all significantly increased. Histoplasmin skin 
      test responses were positive in 18 Type II cases (45%). In the multivariate 
      analysis, only DR2 and the combined presence of DQ1 and a positive histoplasmin 
      skin test remained predictive of Type II disease. Our findings suggest that 
      histoplasmin sensitivity is associated with some, but not all, cases of Type II 
      disease. However, histoplasmin sensitivity appears to have no relationship to 
      Type I disease. HLA factors may play a role in both disease types, possibly by 
      producing a modified immune response to Histoplasma and/or other unidentified 
      agents.
FAU - Derosa, J T
AU  - Derosa JT
AD  - LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat 
      Hospital, New York, USA.
FAU - Yannuzzi, L A
AU  - Yannuzzi LA
FAU - Marmor, M
AU  - Marmor M
FAU - Fotino, M
AU  - Fotino M
FAU - Sorenson, J A
AU  - Sorenson JA
FAU - Spaide, R F
AU  - Spaide RF
LA  - eng
GR  - 5R01-EY04927/EY/NEI NIH HHS/United States
GR  - 5R01-EY06414/EY/NEI NIH HHS/United States
GR  - ES-00260/ES/NIEHS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Doc Ophthalmol
JT  - Documenta ophthalmologica. Advances in ophthalmology
JID - 0370667
RN  - 0 (HLA Antigens)
RN  - 9008-05-3 (Histoplasmin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Child
MH  - Choroid/*blood supply
MH  - Eye Infections, Fungal/complications
MH  - Female
MH  - Fundus Oculi
MH  - HLA Antigens/analysis
MH  - Histocompatibility Testing
MH  - Histoplasmin/immunology
MH  - Histoplasmosis/complications
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neovascularization, Pathologic/*epidemiology/etiology/pathology
MH  - New York/epidemiology
MH  - Risk Factors
MH  - Skin Tests
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1007/BF01204172 [doi]
PST - ppublish
SO  - Doc Ophthalmol. 1995-1996;91(3):207-22. doi: 10.1007/BF01204172.