PMID- 8887317 OWN - NLM STAT- MEDLINE DCOM- 19970306 LR - 20190909 IS - 0925-4773 (Print) IS - 0925-4773 (Linking) VI - 58 IP - 1-2 DP - 1996 Aug TI - Alternate functions of the single-minded and rhomboid genes in development of the Drosophila ventral neuroectoderm. PG - 65-74 AB - We have investigated the roles of the single-minded (sim) and rhomboid (rho) genes in generating distinct cell fates in the Drosophila embryonic neuroectoderm. We show that sim functions to repress ventral ectodermal cell fates, as in sim mutants mesectodermal cells adopt the fates of neighboring ventral ectodermal cells and targeted sim expression in P[paired.Gal4]/P[UAS-sim] embryos results in loss of epidermal cells. We also find that rho is not required for early expression of sim or ventral nervous system defective in mesectodermal or ventral ectodermal cells; targeted rho expression in P[paired-Gal4]/P[UAS-rho] embryos results in lateral-to-ventral cell fate shifts in the developing neuroectoderm; and midline-targeted rho expression can rescue the medial denticle fusions in rho mutant cuticles. FAU - Xiao, H AU - Xiao H AD - Program for Molecular and Cellular Biology, University of Massachusetts at Amherst 01003, USA. FAU - Hrdlicka, L A AU - Hrdlicka LA FAU - Nambu, J R AU - Nambu JR LA - eng GR - NS32251/NS/NINDS NIH HHS/United States PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S. PL - Ireland TA - Mech Dev JT - Mechanisms of development JID - 9101218 RN - 0 (Basic Helix-Loop-Helix Transcription Factors) RN - 0 (DNA-Binding Proteins) RN - 0 (Drosophila Proteins) RN - 0 (Hedgehog Proteins) RN - 0 (Insect Hormones) RN - 0 (Insect Proteins) RN - 0 (Membrane Proteins) RN - 0 (Nuclear Proteins) RN - 0 (Proto-Oncogene Proteins) RN - 0 (Repressor Proteins) RN - 0 (Rho protein, Drosophila) RN - 0 (Stet protein, Drosophila) RN - 0 (Wnt1 Protein) RN - 0 (sim protein, Drosophila) RN - 0 (wg protein, Drosophila) RN - 149291-21-4 (hh protein, Drosophila) SB - IM EIN - Mech Dev 1996 Dec;60(2):243-5 MH - Animals MH - Basic Helix-Loop-Helix Transcription Factors MH - DNA-Binding Proteins/genetics/*physiology MH - Drosophila MH - *Drosophila Proteins MH - Ectoderm/chemistry MH - Embryo, Nonmammalian/chemistry MH - Gene Expression Regulation, Developmental MH - Hedgehog Proteins MH - Helix-Loop-Helix Motifs/genetics/physiology MH - Immunohistochemistry MH - In Situ Hybridization MH - Insect Hormones/genetics/physiology MH - Insect Proteins/metabolism MH - Membrane Proteins/genetics/*physiology MH - Mutation MH - Nuclear Proteins/genetics/*physiology MH - Phenotype MH - Proto-Oncogene Proteins/metabolism MH - Repressor Proteins/genetics/physiology MH - Wnt1 Protein EDAT- 1996/08/01 00:00 MHDA- 1996/08/01 00:01 CRDT- 1996/08/01 00:00 PHST- 1996/08/01 00:00 [pubmed] PHST- 1996/08/01 00:01 [medline] PHST- 1996/08/01 00:00 [entrez] AID - S0925-4773(96)00559-X [pii] AID - 10.1016/s0925-4773(96)00559-x [doi] PST - ppublish SO - Mech Dev. 1996 Aug;58(1-2):65-74. doi: 10.1016/s0925-4773(96)00559-x.