PMID- 8891198
OWN - NLM
STAT- MEDLINE
DCOM- 19970204
LR  - 20191101
IS  - 1016-0922 (Print)
IS  - 1016-0922 (Linking)
VI  - 5
IP  - 4
DP  - 1996 Jul-Aug
TI  - Chemotactic cytokines mediate leukocyte recruitment in fibrotic lung disease.
PG  - 223-31
AB  - In rodents, bleomycin administration results in a route-, dose- and 
      strain-dependent pulmonary inflammatory response. Given intratracheally, this 
      response is characterized by increases in leukocyte accumulation, fibroblast 
      proliferation, and collagen content. We believe that characterization of the cell 
      types and soluble mediators present in the lesion will lend significant insight 
      into the processes modulating pulmonary fibrosis. Recent studies have identified 
      monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1 
      alpha (MIP-1 alpha) as mediators of the inflammatory response in the lungs of 
      human patients afflicted with idiopathic pulmonary fibrosis. Based on this 
      compelling evidence for the involvement of C-C chemokines in fibrotic 
      pathologies, we investigated the roles of MIP-1 alpha and MCP-1 protein in 
      bleomycin-induced lung injury. In this study, we have established that 
      neutralization of MIP-1 alpha and MCP-1 significantly reduces inflammatory cell 
      accumulation. Further, we have shown that passive immunotherapy with either 
      anti-MCP-1 or anti-MIP-1 alpha antibodies significantly reduced mononuclear 
      phagocyte accumulation in bleomycin-challenged mice. These experiments strongly 
      support the hypothesis that MIP-1 alpha and MCP-1 contribute to the recruitment 
      of leukocytes during the pulmonary inflammatory response to bleomycin challenge.
FAU - Smith, R E
AU  - Smith RE
AD  - Department of Pathology, University of Michigan Medical School, Ann Arbor 
      48109-0602, USA.
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Biol Signals
JT  - Biological signals
JID - 9210083
RN  - 0 (Antibodies)
RN  - 0 (Antigens, Surface)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL4)
RN  - 0 (Macrophage Inflammatory Proteins)
RN  - 11056-06-7 (Bleomycin)
SB  - IM
MH  - Animals
MH  - Antibodies
MH  - Antigens, Surface/analysis
MH  - Bleomycin/pharmacology
MH  - Chemokine CCL2/*metabolism
MH  - Chemokine CCL4
MH  - Flow Cytometry
MH  - Humans
MH  - Immunization, Passive
MH  - Leukocytes/*immunology
MH  - Macrophage Inflammatory Proteins/*metabolism
MH  - Mice
MH  - Mice, Inbred CBA
MH  - Pulmonary Fibrosis/*immunology
EDAT- 1996/07/01 00:00
MHDA- 1996/07/01 00:01
CRDT- 1996/07/01 00:00
PHST- 1996/07/01 00:00 [pubmed]
PHST- 1996/07/01 00:01 [medline]
PHST- 1996/07/01 00:00 [entrez]
AID - 10.1159/000109194 [doi]
PST - ppublish
SO  - Biol Signals. 1996 Jul-Aug;5(4):223-31. doi: 10.1159/000109194.