PMID- 8892055
OWN - NLM
STAT- MEDLINE
DCOM- 19970129
LR  - 20220408
IS  - 0946-2716 (Print)
IS  - 0946-2716 (Linking)
VI  - 74
IP  - 9
DP  - 1996 Sep
TI  - Hepatocyte growth factor/scatter factor-Met signaling in tumorigenicity and 
      invasion/metastasis.
PG  - 505-13
AB  - Hepatocyte growth factor/scatter factor (HGF/SF) is a pleiotropic effector of 
      cells expressing the Met tyrosine kinase receptor. While HGF/SF-Met signaling 
      clearly plays a role in a variety of normal cellular process, this signaling 
      pathway has also been implicated in the generation and metastatic spread of 
      tumors. This review discusses in detail several model systems that have been 
      developed to investigate the role of HGF/SF-Met signaling in malignancy and 
      describes additional data regarding the expression of these molecules in human 
      tumors. Collectively the findings support a role for this receptor-ligand pair in 
      human malignancy.
FAU - Jeffers, M
AU  - Jeffers M
AD  - ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, 
      MD 21702, USA.
FAU - Rong, S
AU  - Rong S
FAU - Vande Woude, G F
AU  - Vande Woude GF
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - Germany
TA  - J Mol Med (Berl)
JT  - Journal of molecular medicine (Berlin, Germany)
JID - 9504370
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
SB  - IM
MH  - Animals
MH  - Gene Expression Regulation/genetics
MH  - Hepatocyte Growth Factor/*metabolism
MH  - Humans
MH  - Mice
MH  - Models, Biological
MH  - Neoplasm Metastasis
MH  - Neoplasms/metabolism
MH  - Protein-Tyrosine Kinases/metabolism
MH  - Signal Transduction/physiology
MH  - Tumor Cells, Cultured
RF  - 106
EDAT- 1996/09/01 00:00
MHDA- 1996/09/01 00:01
CRDT- 1996/09/01 00:00
PHST- 1996/09/01 00:00 [pubmed]
PHST- 1996/09/01 00:01 [medline]
PHST- 1996/09/01 00:00 [entrez]
AID - 10.1007/BF00204976 [doi]
PST - ppublish
SO  - J Mol Med (Berl). 1996 Sep;74(9):505-13. doi: 10.1007/BF00204976.