PMID- 8892094
OWN - NLM
STAT- MEDLINE
DCOM- 19970314
LR  - 20190116
IS  - 0360-4012 (Print)
IS  - 0360-4012 (Linking)
VI  - 45
IP  - 6
DP  - 1996 Sep 15
TI  - Human T lymphocytes specific for the immunodominant 83-99 epitope of myelin basic 
      protein: recognition of golli MBP HOG 7.
PG  - 820-8
AB  - Myelin basic protein (MBP) is a candidate autoantigen in the disease multiple 
      sclerosis. Although MBP was thought to be sequestered behind the blood-brain 
      barrier, isoforms of MBPs have recently been demonstrated in lymphoid tissues. 
      These isoforms, termed golli MBPs, contain sequences that are shared with 
      "classic" MBP within the CNS. In the present study, we have determined that 
      epitopes within golli MBP isoforms may be recognized by human T lymphocyte clones 
      specific for classic MBP. Ten of 12 T-cell clones recognized golli MBP. Although 
      11 clones were specific for the immunodominant 83-99 sequence, the clones 
      differed with respect to human leukocyte antigen (HLA) restriction, T-helper 
      phenotype, cytolytic activity, and T-cell receptor usage. Greater responses to 
      classic MBP than to golli MBP suggested a difference in the ability of the two 
      proteins to be processed and to present epitopes therein. These data advance the 
      hypothesis that golli MBP sequences expressed within lymphoid tissues may be 
      recognized by classic MBP-specific T lymphocytes during central or peripheral 
      tolerance.
FAU - Tranquill, L R
AU  - Tranquill LR
AD  - Neuroimmunology Branch, National Instututes of Health, Bethesda, Maryland, USA.
FAU - Skinner, E
AU  - Skinner E
FAU - Campagnoni, C
AU  - Campagnoni C
FAU - Vergelli, M
AU  - Vergelli M
FAU - Hemmer, B
AU  - Hemmer B
FAU - Muraro, P
AU  - Muraro P
FAU - Martin, R
AU  - Martin R
FAU - McFarland, H F
AU  - McFarland HF
FAU - Campagnoni, A T
AU  - Campagnoni AT
FAU - Voskuhl, R R
AU  - Voskuhl RR
LA  - eng
GR  - NS33091/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (Epitopes, T-Lymphocyte)
RN  - 0 (Immunodominant Epitopes)
RN  - 0 (Myelin Basic Protein)
SB  - IM
MH  - *Antibody Specificity
MH  - Antigen-Antibody Reactions
MH  - Case-Control Studies
MH  - Clone Cells
MH  - *Epitopes, T-Lymphocyte
MH  - Humans
MH  - Immune Tolerance
MH  - *Immunodominant Epitopes
MH  - Multiple Sclerosis/*immunology
MH  - Myelin Basic Protein/*immunology
MH  - T-Lymphocytes/*immunology
EDAT- 1996/09/15 00:00
MHDA- 2000/06/20 09:00
CRDT- 1996/09/15 00:00
PHST- 1996/09/15 00:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1996/09/15 00:00 [entrez]
AID - 10.1002/(SICI)1097-4547(19960915)45:6<820::AID-JNR19>3.0.CO;2-Z [pii]
AID - 10.1002/(SICI)1097-4547(19960915)45:6<820::AID-JNR19>3.0.CO;2-Z [doi]
PST - ppublish
SO  - J Neurosci Res. 1996 Sep 15;45(6):820-8. doi: 
      10.1002/(SICI)1097-4547(19960915)45:6<820::AID-JNR19>3.0.CO;2-Z.