PMID- 8892591
OWN - NLM
STAT- MEDLINE
DCOM- 19961213
LR  - 20190722
IS  - 0046-8177 (Print)
IS  - 0046-8177 (Linking)
VI  - 27
IP  - 10
DP  - 1996 Oct
TI  - Overexpression of bcl-2 protein in synovial sarcoma: a comparative study of other 
      soft tissue spindle cell sarcomas and an additional analysis by fluorescence in 
      situ hybridization.
PG  - 1060-5
AB  - The expression of bcl-2 protein was analyzed in 19 synovial sarcomas and 29 
      additional soft tissue spindle cell sarcomas as controls by the immunohistologic 
      staining of paraffin-embedded specimens; 15 of 19 (79%) synovial sarcoma cases 
      were positive, but all other spindle cell sarcomas were negative including 20 
      leiomyosarcomas, 4 malignant peripheral nerve sheath tumors, and 4 fibrosarcomas. 
      In 4 cases of bcl-2-positive synovial sarcoma (3 biphasic and 1 focally glandular 
      type), bcl-2 protein staining was much stronger in the spindle cells than in the 
      epithelial cells. A fluorescence in situ hybridization (FISH) analysis with 
      centromeric and whole chromosome painting probes for chromosome 18 and X was 
      performed on 7 synovial sarcomas. The six cases of bcl-2-positive synovial 
      sarcoma consisted of five cases with the t(X; 18) and one case with tetrasomy of 
      chromosome 18 and X. It has been speculated that bcl-2 protein expression is 
      caused by the 14; 18 translocation and other abnormalities of chromosome 18. This 
      study thus showed the feasibility of such a correlation between bcl-2 protein 
      expression and the characteristic cytogenetic abnormality in the synovial 
      sarcoma-X; 18 translocation. In addition, bcl-2 protein also appears to be a 
      characteristic marker of synovial sarcoma and is thus considered to be 
      potentially useful in distinguishing synovial sarcoma from other spindle cell 
      sarcomas.
FAU - Hirakawa, N
AU  - Hirakawa N
AD  - Second Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, 
      Japan.
FAU - Naka, T
AU  - Naka T
FAU - Yamamoto, I
AU  - Yamamoto I
FAU - Fukuda, T
AU  - Fukuda T
FAU - Tsuneyoshi, M
AU  - Tsuneyoshi M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Pathol
JT  - Human pathology
JID - 9421547
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
SB  - IM
MH  - Chromosomes, Human, Pair 18
MH  - Cytogenetics
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - *In Situ Hybridization, Fluorescence
MH  - Male
MH  - Proto-Oncogene Proteins c-bcl-2/analysis/*biosynthesis
MH  - Sarcoma/*chemistry/pathology
MH  - Sarcoma, Synovial/*chemistry/pathology
MH  - Soft Tissue Neoplasms/*chemistry/pathology
MH  - X Chromosome
EDAT- 1996/10/01 00:00
MHDA- 1996/10/01 00:01
CRDT- 1996/10/01 00:00
PHST- 1996/10/01 00:00 [pubmed]
PHST- 1996/10/01 00:01 [medline]
PHST- 1996/10/01 00:00 [entrez]
AID - S0046-8177(96)90284-1 [pii]
AID - 10.1016/s0046-8177(96)90284-1 [doi]
PST - ppublish
SO  - Hum Pathol. 1996 Oct;27(10):1060-5. doi: 10.1016/s0046-8177(96)90284-1.