PMID- 8895686
OWN - NLM
STAT- MEDLINE
DCOM- 19961223
LR  - 20181130
IS  - 0361-8609 (Print)
IS  - 0361-8609 (Linking)
VI  - 53
IP  - 3
DP  - 1996 Nov
TI  - Serum dehydroepiandrosterone and DHEA-sulfate in patients with adult T-cell 
      leukemia and human T-lymphotropic virus type I carriers.
PG  - 165-8
AB  - The serum levels of dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEA-S) were 
      determined by radioimmunoassay in 38 patients with adult T-cell leukemia (ATL). 
      Levels of serum DHEA and DHEA-S were also measured in 60 human T-lymphotropic 
      virus type I (HTLV-I) carriers, and did not differ from those in 60 healthy 
      control subjects. Serum levels in patients with ATL were lower than those in the 
      age- and sex-matched healthy controls and in HTLV-I carriers with statistical 
      significance. Serum DHEA and DHEA-S in male patients with acute and lymphoma-type 
      ATL were 1.06 +/- 0.77 ng/ml and 245.8 +/- 192.9 ng/ml, respectively. Levels in 
      male patients with chronic and smoldering-type ATL were 1.69 +/- 0.68 ng/ml and 
      477.6 +/- 251.5 ng/ml, respectively. Serum levels of DHEA and DHEA-S in patients 
      with acute and lymphoma-type ATL were significantly lower than those in patients 
      with chronic and smoldering-type ATL (P < 0.05). These data suggest that a 
      decrease in serum levels of DHEA and DHEA-S may be associated with patients who 
      have some clinical subtypes of ATL. Moreover, androgens may have a therapeutic 
      role in patients with ATL, as administered in patients with hairy-cell leukemia. 
      Because there is at present no curative chemotherapy for ATL, a trial combination 
      of androgens and standard chemotherapy may be a reasonable therapeutic option in 
      such patients.
FAU - Uozumi, K
AU  - Uozumi K
AD  - Second Department of Internal Medicine, Faculty of Medicine, Kagoshima 
      University, Japan.
FAU - Uematsu, T
AU  - Uematsu T
FAU - Otsuka, M
AU  - Otsuka M
FAU - Nakano, S
AU  - Nakano S
FAU - Takatsuka, Y
AU  - Takatsuka Y
FAU - Iwahashi, M
AU  - Iwahashi M
FAU - Hanada, S
AU  - Hanada S
FAU - Arima, T
AU  - Arima T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Hematol
JT  - American journal of hematology
JID - 7610369
RN  - 459AG36T1B (Dehydroepiandrosterone)
RN  - 57B09Q7FJR (Dehydroepiandrosterone Sulfate)
SB  - IM
MH  - Adrenal Cortex/metabolism
MH  - Adult
MH  - Aged
MH  - Carrier State/*blood
MH  - Dehydroepiandrosterone/*blood/deficiency/physiology
MH  - Dehydroepiandrosterone Sulfate/*blood
MH  - Female
MH  - HTLV-I Infections/*blood
MH  - Humans
MH  - Immunocompetence/physiology
MH  - Leukemia-Lymphoma, Adult T-Cell/*blood/immunology/pathology
MH  - Male
MH  - Middle Aged
EDAT- 1996/11/01 00:00
MHDA- 2000/06/20 09:00
CRDT- 1996/11/01 00:00
PHST- 1996/11/01 00:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1996/11/01 00:00 [entrez]
AID - 10.1002/(SICI)1096-8652(199611)53:3<165::AID-AJH3>3.0.CO;2-X [pii]
AID - 10.1002/(SICI)1096-8652(199611)53:3<165::AID-AJH3>3.0.CO;2-X [doi]
PST - ppublish
SO  - Am J Hematol. 1996 Nov;53(3):165-8. doi: 
      10.1002/(SICI)1096-8652(199611)53:3<165::AID-AJH3>3.0.CO;2-X.