PMID- 8896070
OWN - NLM
STAT- MEDLINE
DCOM- 19970213
LR  - 20111117
IS  - 1169-8446 (Print)
IS  - 1169-8446 (Linking)
VI  - 63
IP  - 7-8
DP  - 1996 Jul-Sep
TI  - Immunogenetic studies of Behcet's disease.
PG  - 520-7
AB  - Behcet's disease has been shown to be strongly associated with the human 
      leukocyte antigen (HLA) B51, not only in the Japanese but also in many other 
      ethnic groups living in the area that extends from the Middle East to Japan. 
      Specific antigen presentation by B51 molecules may be involved in the development 
      of Behcet's disease. Furthermore, studies of the HLA-C genotype conducted using a 
      polymerase chain reaction-sequence specific primers method have suggested that 
      the gene involved in the pathogenesis of Behcet's disease is not the HLA-C gene 
      but some other gene located near the HLA-B gene. Polymorphic analysis of the 
      Tau-a microsatellite located between the HLA-B and TNF genes have also indicated 
      that the Behcet's disease gene is located near the HLA-B gene but is not the 
      HLA-B51 gene itself. We and others believe that many important genes exist in the 
      region located between the TNF and HLA-B or HLA-C genes, including the MIC, PERB, 
      and NOB genes. In this paper, we review current data on genetic factors involved 
      in the development of Behcet's disease.
FAU - Mizuki, N
AU  - Mizuki N
AD  - Department of Ophthalmology, Yokohama City, University School of Medicine, Japan.
FAU - Ohno, S
AU  - Ohno S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - France
TA  - Rev Rhum Engl Ed
JT  - Revue du rhumatisme (English ed.)
JID - 9313916
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B51 Antigen)
RN  - 0 (HLA-C Antigens)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - *Behcet Syndrome/genetics/immunology
MH  - Gene Expression
MH  - *HLA-B Antigens/genetics/immunology
MH  - HLA-B51 Antigen
MH  - HLA-C Antigens/genetics/immunology
MH  - Humans
MH  - Polymorphism, Genetic
MH  - Tumor Necrosis Factor-alpha/genetics/immunology
RF  - 28
EDAT- 1996/07/01 00:00
MHDA- 1996/07/01 00:01
CRDT- 1996/07/01 00:00
PHST- 1996/07/01 00:00 [pubmed]
PHST- 1996/07/01 00:01 [medline]
PHST- 1996/07/01 00:00 [entrez]
PST - ppublish
SO  - Rev Rhum Engl Ed. 1996 Jul-Sep;63(7-8):520-7.