PMID- 8896242
OWN - NLM
STAT- MEDLINE
DCOM- 19970206
LR  - 20190909
IS  - 0168-1702 (Print)
IS  - 0168-1702 (Linking)
VI  - 45
IP  - 2
DP  - 1996 Dec
TI  - Growth of human herpesvirus 6 in HEPG2 cells.
PG  - 75-85
AB  - HepG2 cells, a well differentiated liver cell line, were shown to be permissive 
      for both human herpesvirus 6 (HHV-6) A and B strains by three independent methods 
      of analysis: detection of viral antigens, viral DNA sequences and infectious 
      virus. HepG2 cell infection with HHV-6 resulted in functional damage as shown by 
      the increased release in the culture medium of some hepatocyte markers. Cells 
      surviving the acute infection were serially passaged without showing cytopathic 
      effect, but, some months later, HHV-6 DNA was still present in the cells and 
      virus induction with a phorbol ester was successful. A possible pathogenetic role 
      of HHV-6 in liver diseases is discussed. Experiments of HepG2 infection with 
      human herpesvirus 7 (HHV-7) were also carried out. The lack of an efficient virus 
      replication suggested a difficulty for HHV-7 to infect hepatic cells.
FAU - Cermelli, C
AU  - Cermelli C
AD  - Department of Biomedical Sciences, University of Modena, Italy.
FAU - Concari, M
AU  - Concari M
FAU - Carubbi, F
AU  - Carubbi F
FAU - Fabio, G
AU  - Fabio G
FAU - Sabbatini, A M
AU  - Sabbatini AM
FAU - Pecorari, M
AU  - Pecorari M
FAU - Pietrosemoli, P
AU  - Pietrosemoli P
FAU - Meacci, M
AU  - Meacci M
FAU - Guicciardi, E
AU  - Guicciardi E
FAU - Carulli, N
AU  - Carulli N
FAU - Portolani, M
AU  - Portolani M
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Virus Res
JT  - Virus research
JID - 8410979
RN  - 0 (DNA, Viral)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Viral Proteins)
RN  - 138415-18-6 (p41 protein, Human herpesvirus 6)
SB  - IM
MH  - Cells, Cultured
MH  - Cytopathogenic Effect, Viral
MH  - DNA, Viral/analysis
MH  - DNA-Binding Proteins/genetics/metabolism
MH  - Fetal Blood/cytology
MH  - Herpesvirus 6, Human/genetics/*growth & development/metabolism
MH  - Herpesvirus 7, Human/*growth & development
MH  - Humans
MH  - Tumor Cells, Cultured
MH  - Viral Proteins/genetics/metabolism
EDAT- 1996/12/01 00:00
MHDA- 1996/12/01 00:01
CRDT- 1996/12/01 00:00
PHST- 1996/12/01 00:00 [pubmed]
PHST- 1996/12/01 00:01 [medline]
PHST- 1996/12/01 00:00 [entrez]
AID - S0168-1702(96)01364-0 [pii]
AID - 10.1016/s0168-1702(96)01364-0 [doi]
PST - ppublish
SO  - Virus Res. 1996 Dec;45(2):75-85. doi: 10.1016/s0168-1702(96)01364-0.