PMID- 8896808
OWN - NLM
STAT- MEDLINE
DCOM- 19970218
LR  - 20170301
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 734
IP  - 1-2
DP  - 1996 Sep 23
TI  - Central antagonism of atrial natriuretic peptides on behavioral and hormonal 
      responses to angiotensin II: mapping with c-fos.
PG  - 55-60
AB  - The expression of the immediate early gene (IEG) c-fos has been used to map the 
      antagonistic effects between atrial natriuretic peptide (ANP) and angiotensin II 
      (Ang II). Intracerebroventricular (i.c.v.) infusions of ANP (100, 250, 1000 or 
      2000 pmol) did not induce detectable c-fos expression in the forebrain when 
      compared with CSF-treated rats. Neither did C-type natriuretic peptide (CNP, 10, 
      100, 500 or 1000 pmol), another member of the natriuretic peptide family, which 
      appears to be predominant in the brain. ANP was found to inhibit the water intake 
      and corticosterone release induced by i.c.v. infusions of Ang II. However, ANP 
      could not suppress the c-fos expression in the organum vasculosum of the lamina 
      terminalis (OVLT), medial preoptic nucleus (MNPO), subfornical organ (SFO), 
      supraoptic (SON) and paraventricular (PVN) nuclei of forebrain induced by the 
      same dose of Ang II. The activation of second messenger pathways following i.c.v. 
      infusion of Ang II may result in two different sets of effects: immediate 
      behavioural and physiological responses (presumably through postsynpatic 
      responses in neurons sensitive to Ang II), and the delayed expression of c-fos 
      (and other IEGs proteins) which control the expression of late response genes. 
      Whilst there is considerable, and growing evidence that IEGs mark the pattern of 
      neuronal activity induced by peptides such as Ang II, the precise role played by 
      these gene products is still problematical and awaits clarification by further 
      experiments.
FAU - Zhu, B
AU  - Zhu B
AD  - Department of Anatomy, University of Cambridge, UK.
FAU - Herbert, J
AU  - Herbert J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Hormones)
RN  - 0 (Proteins)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 11128-99-7 (Angiotensin II)
RN  - 127869-51-6 (Natriuretic Peptide, C-Type)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Angiotensin II/*pharmacology
MH  - Animals
MH  - Atrial Natriuretic Factor/*antagonists & inhibitors/pharmacology
MH  - Behavior, Animal/*physiology
MH  - Brain/drug effects/*metabolism
MH  - Corticosterone/metabolism
MH  - Drinking/drug effects
MH  - Hormones/*metabolism
MH  - Injections, Intraventricular
MH  - Male
MH  - Microinjections
MH  - Natriuretic Peptide, C-Type
MH  - Proteins/*pharmacology
MH  - Proto-Oncogene Proteins c-fos/*metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Tissue Distribution
EDAT- 1996/09/23 00:00
MHDA- 1996/09/23 00:01
CRDT- 1996/09/23 00:00
PHST- 1996/09/23 00:00 [pubmed]
PHST- 1996/09/23 00:01 [medline]
PHST- 1996/09/23 00:00 [entrez]
AID - 0006-8993(96)00615-4 [pii]
PST - ppublish
SO  - Brain Res. 1996 Sep 23;734(1-2):55-60.