PMID- 8899048
OWN - NLM
STAT- MEDLINE
DCOM- 19970221
LR  - 20190814
IS  - 0001-6314 (Print)
IS  - 0001-6314 (Linking)
VI  - 94
IP  - 3
DP  - 1996 Sep
TI  - Distribution of HLA-Dw2 in optic neuritis and multiple sclerosis indicates 
      heterogeneity.
PG  - 161-6
AB  - The human leukocyte antigen (HLA) phenotype Dw2 is known to be increased in 
      multiple sclerosis (MS), but only slightly in optic neuritis (ON). MATERIAL AND 
      METHODS: 127 consecutive patients with unilateral monosymptomatic ON were typed 
      genomically for HLA-DR and -DQ genes. RESULTS: The frequency of HLA-Dw2 among ON 
      patients (47%) was found to be significantly higher than among 250 controls (30%) 
      but significantly lower than in a group of 245 MS patients (60%), all of the same 
      ethnic origin. At the group level, these figures can be calculated to indicate 
      that 53% of the ON patients belong to the group of "MS-type ON" (95% confidence 
      limits 25-78%). A compilation of published data on the frequency of the 
      HLA-DR17(3), DQ2 haplotype, prompted by a slight increase in this material, 
      revealed a significant association with this haplotype in ON, after compensation 
      for the increase of Dw2. CONCLUSION: ON differs from both MS and controls 
      regarding HLA-Dw2. Thus, a substantial number of patients with ON may suffer from 
      conditions not immuno-genetically related to MS, which might be designated as 
      non-MS type ON. This condition may be more common in men and in young patients of 
      both sexes.
FAU - Hillert, J
AU  - Hillert J
AD  - NOVUM, Department of Neurology, Huddinge, Sweden.
FAU - Kall, T
AU  - Kall T
FAU - Olerup, O
AU  - Olerup O
FAU - Soderstrom, M
AU  - Soderstrom M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Acta Neurol Scand
JT  - Acta neurologica Scandinavica
JID - 0370336
RN  - 0 (HLA-D Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Gene Frequency/genetics
MH  - HLA-D Antigens/*genetics
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DR Antigens/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/diagnosis/*genetics
MH  - Optic Neuritis/diagnosis/*genetics
MH  - Phenotype
MH  - Risk Factors
EDAT- 1996/09/01 00:00
MHDA- 1996/09/01 00:01
CRDT- 1996/09/01 00:00
PHST- 1996/09/01 00:00 [pubmed]
PHST- 1996/09/01 00:01 [medline]
PHST- 1996/09/01 00:00 [entrez]
AID - 10.1111/j.1600-0404.1996.tb07047.x [doi]
PST - ppublish
SO  - Acta Neurol Scand. 1996 Sep;94(3):161-6. doi: 10.1111/j.1600-0404.1996.tb07047.x.