PMID- 8899199
OWN - NLM
STAT- MEDLINE
DCOM- 19970317
LR  - 20071115
IS  - 0268-3369 (Print)
IS  - 0268-3369 (Linking)
VI  - 18
IP  - 4
DP  - 1996 Oct
TI  - Durable molecular remission in a patient with chronic myelogenous leukemia and 
      host-derived hematopoiesis after allogeneic bone marrow transplantation.
PG  - 801-4
AB  - A 44-year-old woman with Ph-positive CML was treated with TBI, splenic 
      irradiation, Ara-C, and CY. She then received unmanipulated marrow cells from her 
      HLA-identical brother. GVHD prophylaxis was FK506 and MTX. WBC counts reached 
      1000/microliter on day 28 when all metaphases of marrow cells showed 46XY. 
      However, on day 42, 46XX was detected in two of 20 metaphases, and the percentage 
      of cells with female karyotype subsequently increased. On day 519, all metaphases 
      showed female karyotype. BCR-ABL mRNA and Philadelphia chromosome were never 
      detected throughout her post-transplant course. Fluorescence in situ 
      hybridization (FISH) revealed complete recovery of host-derived hematopoiesis in 
      the bone marrow, however, mixed T cell chimerism in the peripheral blood. This 
      suggests that the persistence of donor-derived T cells may prevent disease 
      recurrence through graft-versus-leukemia effect. The patient remains in a 
      molecular complete remission with host-derived hematopoiesis 749 days 
      post-transplant.
FAU - Wakui, M
AU  - Wakui M
AD  - Bone Marrow Transplant Program, School of Medicine Keio University, Tokyo, Japan.
FAU - Okamoto, S
AU  - Okamoto S
FAU - Ishida, A
AU  - Ishida A
FAU - Tanosaki, R
AU  - Tanosaki R
FAU - Mori, T
AU  - Mori T
FAU - Kawai, Y
AU  - Kawai Y
FAU - Ohshima, S
AU  - Ohshima S
FAU - Ikeda, Y
AU  - Ikeda Y
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
SB  - IM
MH  - Adult
MH  - *Bone Marrow Transplantation
MH  - Chimera/genetics
MH  - Female
MH  - Genes, abl
MH  - Graft vs Host Reaction/genetics/immunology
MH  - Hematopoiesis/genetics/immunology
MH  - Humans
MH  - Karyotyping
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics/pathology/*therapy
MH  - Leukemia, Myeloid, Chronic-Phase/genetics/pathology/*therapy
MH  - Male
MH  - T-Lymphocytes/immunology
MH  - Transplantation Conditioning
MH  - Transplantation, Homologous
MH  - X Chromosome
MH  - Y Chromosome
EDAT- 1996/10/01 00:00
MHDA- 1996/10/01 00:01
CRDT- 1996/10/01 00:00
PHST- 1996/10/01 00:00 [pubmed]
PHST- 1996/10/01 00:01 [medline]
PHST- 1996/10/01 00:00 [entrez]
PST - ppublish
SO  - Bone Marrow Transplant. 1996 Oct;18(4):801-4.