PMID- 8899890
OWN - NLM
STAT- MEDLINE
DCOM- 19970303
LR  - 20190830
IS  - 0167-0115 (Print)
IS  - 0167-0115 (Linking)
VI  - 66
IP  - 1-2
DP  - 1996 Oct 8
TI  - Centrally administered losartan inhibits the reduction in plasma renin 
      concentration caused by intracerebroventricular hypertonic saline in Na-depleted 
      sheep.
PG  - 37-40
AB  - Infusions (at 1 ml/h) of two different hypertonic solutions were made into the 
      lateral cerebral ventricle of Na-depleted sheep and the effect on plasma renin 
      concentration (PRC) was investigated. Intracerebroventricular (i.c.v.) infusion 
      of 0.75 mol/l NaCl caused a large reduction in plasma renin concentration whereas 
      i.c.v. infusions of hypertonic 1.2 mol/l sorbitol in 0.15 mol/l NaCl or isotonic 
      artificial cerebrospinal fluid did not. An i.c.v. infusion of the angiotensin AT1 
      receptor antagonist losartan (1 mg/ml per h for 2.5 h) commencing 1 h prior to 
      i.c.v. 0.75 mol/l NaCl prevented the reduction in PRC induced by i.c.v. 
      hypertonic NaCl. No change in arterial pressure occurred with any of these i.c.v. 
      infusions in Na-depleted sheep. The results suggest that a central 
      angiotensinergic mechanism may be involved in central pathways inhibiting renin 
      secretion by the kidney.
FAU - McKinley, M J
AU  - McKinley MJ
AD  - Howard Florey Institute of Experimental Physiology and Medicine, University of 
      Melbourne, Parkville, Victoria, Australia.
FAU - Mathai, M L
AU  - Mathai ML
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Regul Pept
JT  - Regulatory peptides
JID - 8100479
RN  - 0 (Angiotensin Receptor Antagonists)
RN  - 0 (Biphenyl Compounds)
RN  - 0 (Diuretics, Osmotic)
RN  - 0 (Imidazoles)
RN  - 0 (Saline Solution, Hypertonic)
RN  - 0 (Tetrazoles)
RN  - 11000-17-2 (Vasopressins)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - 506T60A25R (Sorbitol)
RN  - 9NEZ333N27 (Sodium)
RN  - EC 3.4.23.15 (Renin)
RN  - JMS50MPO89 (Losartan)
SB  - IM
MH  - *Angiotensin Receptor Antagonists
MH  - Animals
MH  - Biphenyl Compounds/administration & dosage/*pharmacology
MH  - Blood Pressure/drug effects/*physiology
MH  - Diuretics, Osmotic/administration & dosage/pharmacology
MH  - Female
MH  - Imidazoles/administration & dosage/*pharmacology
MH  - Injections, Intraventricular
MH  - Losartan
MH  - Ovariectomy
MH  - Renin/*blood/drug effects/metabolism
MH  - Saline Solution, Hypertonic/administration & dosage/*pharmacology
MH  - Sheep
MH  - Sodium/*deficiency
MH  - Sodium Chloride/administration & dosage/pharmacology
MH  - Sorbitol/administration & dosage/pharmacology
MH  - Tetrazoles/administration & dosage/*pharmacology
MH  - Time Factors
MH  - Vasopressins/blood
EDAT- 1996/10/08 00:00
MHDA- 1996/10/08 00:01
CRDT- 1996/10/08 00:00
PHST- 1996/10/08 00:00 [pubmed]
PHST- 1996/10/08 00:01 [medline]
PHST- 1996/10/08 00:00 [entrez]
AID - 0167-0115(96)00047-X [pii]
AID - 10.1016/0167-0115(96)00047-x [doi]
PST - ppublish
SO  - Regul Pept. 1996 Oct 8;66(1-2):37-40. doi: 10.1016/0167-0115(96)00047-x.