PMID- 8900380
OWN - NLM
STAT- MEDLINE
DCOM- 19961206
LR  - 20190717
IS  - 0002-9629 (Print)
IS  - 0002-9629 (Linking)
VI  - 312
IP  - 5
DP  - 1996 Nov
TI  - Role of urinary arginine vasopressin in the sodium excretion in patients with 
      chronic renal failure.
PG  - 195-201
AB  - Patients with chronic renal failure show almost equal levels of sodium excreted 
      in the urine as healthy subjects through an increase of the fractional excretion 
      sodium (FE(Na)). The mechanisms of this adaptation, however, are unknown. 
      Recently, urinary arginine vasopressin (AVP) has been shown to inhibit the 
      antidiuretic action of plasma AVP in the collecting ducts of rabbits and rats. In 
      this article, the roles of plasma and urinary AVP are examined with other 
      hormones in the sodium excretion of 57 patients with chronic renal disease. The 
      fractional excretion of AVP, plasma atrial natriuretic peptide (ANP) and 
      endothelin-1 (ET-1), urinary ET-1, and FE(ET-1) correlated with the decrease of 
      creatinine clearance (Ccr). Multiple and stepwise regression analyses showed that 
      FE(AVP) is the major dependent determinant for FE(Na) (adjusted r2 = 0.78). These 
      results suggest that the increase of AVP excretion per remaining nephron could be 
      a cause of the increase of FE(Na) in patients with renal failure. Although plasma 
      AVP works as an antidiuretic hormone, urinary AVP serves as an intrinsic 
      diuretic, especially in patients with chronic renal failure.
FAU - Nonoguchi, H
AU  - Nonoguchi H
AD  - Third Department of Internal Medicine, Kumamoto University School of Medicine, 
      Japan.
FAU - Takayama, M
AU  - Takayama M
FAU - Owada, A
AU  - Owada A
FAU - Ujiie, K
AU  - Ujiie K
FAU - Yamada, T
AU  - Yamada T
FAU - Nakashima, O
AU  - Nakashima O
FAU - Sakuma, Y
AU  - Sakuma Y
FAU - Koike, J
AU  - Koike J
FAU - Terada, Y
AU  - Terada Y
FAU - Marumo, F
AU  - Marumo F
FAU - Tomita, K
AU  - Tomita K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
RN  - 0 (Endothelin-1)
RN  - 113-79-1 (Arginine Vasopressin)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
RN  - 9NEZ333N27 (Sodium)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Arginine Vasopressin/blood/*urine
MH  - Atrial Natriuretic Factor/blood
MH  - Child
MH  - Endothelin-1/blood
MH  - Female
MH  - Humans
MH  - Kidney Failure, Chronic/*urine
MH  - Male
MH  - Middle Aged
MH  - Regression Analysis
MH  - Sodium/*urine
EDAT- 1996/11/01 00:00
MHDA- 1996/11/01 00:01
CRDT- 1996/11/01 00:00
PHST- 1996/11/01 00:00 [pubmed]
PHST- 1996/11/01 00:01 [medline]
PHST- 1996/11/01 00:00 [entrez]
AID - S0002-9629(15)41815-4 [pii]
AID - 10.1097/00000441-199611000-00001 [doi]
PST - ppublish
SO  - Am J Med Sci. 1996 Nov;312(5):195-201. doi: 10.1097/00000441-199611000-00001.