PMID- 8900460
OWN - NLM
STAT- MEDLINE
DCOM- 19961227
LR  - 20211203
IS  - 0024-4201 (Print)
IS  - 0024-4201 (Linking)
VI  - 31
IP  - 3
DP  - 1996 Mar
TI  - Long-chain polyunsaturated fatty acids in plasma lipids of obese children.
PG  - 305-11
AB  - Fatty acid composition of plasma phospholipids (PL), triglycerides (TG), and 
      sterol esters (STE) was determined by high-resolution capillary gas-liquid 
      chromatography in 22 obese children (age: 13.7 +/- 1.4 y, body weight relative to 
      normal weight for height: 170 +/- 24%, mean +/- SD) and compared with data 
      obtained in 25 age-matched healthy controls. There were no differences in the 
      levels of linoleic acid (LA, C18:2n-6) in any of the plasma fractions from obese 
      children and the controls. Obese children exhibited significantly higher values 
      of arachidonic acid (AA, C20:4n-6) than controls both in PL (12.6 [2.4] vs. 8.3 
      [1.4], % wt/wt, [median (interquartile range)], P < 0.001) and STE (7.3 [1.8] vs. 
      6.0 [1.1], P < 0.05). Similarly, obese children showed higher values than 
      controls for dihomo-gamma-linoleic acid (DHGLA, C20:3n-6) in PL (4.0 [0.5] vs. 
      3.0 [0.6], P < 0.001), TG (0.4 [0.1] vs. 0.2 [0.1], P < 0.001), and STE (0.9 
      [0.1] vs. 0.7 [0.1], P < 0.01), and for gamma-linolenic acid (C18:3n-6) in STE 
      (1.1 [0.2] vs. 0.8 [0.2], P < 0.001). The AA/LA ratios were higher in obese 
      children than in controls in PL (0.68 [0.16] vs. 0.42 [0.09], P < 0.0005) and STE 
      (0.16 [0.04] vs. 0.12 [0.02], P < 0.05), whereas the AA/DHGLA ratios were lower 
      in TG of obese children than in controls (3.40 [0.64] vs. 5.10 [1.75], P < 
      0.005). Plasma glucose concentrations were inversely related to AA in TG (r = 
      0.53, P < 0.05), and plasma TG concentrations were inversely related to AA in PL 
      and STE (r = -0.49, P < 0.05 and r = -0.48, P < 0.05) and to the AA/DHGLA ratios 
      in PL (r = -0.57, P < 0.01), TG (r = -0.56, P < 0.01), and STE (r = -0.56, P < 
      0.01). We conclude that the significantly higher values of n-6 long-chain 
      polyunsaturated fatty acids (LCP) in plasma lipids of obese children than in 
      age-matched controls may be caused by an enhanced activity of delta 
      6-desaturation, and we speculate that elevated fasting immunoreactive insulin 
      seen in obese children (19.4 +/- 8.0 microU/mL) may stimulate synthesis of n-6 
      LCP fatty acids.
FAU - Decsi, T
AU  - Decsi T
AD  - Department of Paediatrics, University Medical School of Pecs, Hungary.
FAU - Molnar, D
AU  - Molnar D
FAU - Koletzko, B
AU  - Koletzko B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Lipids
JT  - Lipids
JID - 0060450
RN  - 0 (Blood Glucose)
RN  - 0 (Delta-5 Fatty Acid Desaturase)
RN  - 0 (Fatty Acids)
RN  - 0 (Fatty Acids, Omega-6)
RN  - 0 (Fatty Acids, Unsaturated)
RN  - 0 (Insulin)
RN  - 0 (Phospholipids)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - EC 1.14.19.- (Fatty Acid Desaturases)
SB  - IM
MH  - Adolescent
MH  - Blood Glucose/analysis
MH  - Body Weight
MH  - Cholesterol/blood
MH  - Delta-5 Fatty Acid Desaturase
MH  - Fatty Acid Desaturases/metabolism
MH  - Fatty Acids/blood/chemistry
MH  - Fatty Acids, Omega-6
MH  - Fatty Acids, Unsaturated/analysis/*blood/metabolism
MH  - Female
MH  - Humans
MH  - Insulin/blood
MH  - Male
MH  - Obesity/*metabolism
MH  - Phospholipids/blood
MH  - Triglycerides/blood
EDAT- 1996/03/01 00:00
MHDA- 1996/03/01 00:01
CRDT- 1996/03/01 00:00
PHST- 1996/03/01 00:00 [pubmed]
PHST- 1996/03/01 00:01 [medline]
PHST- 1996/03/01 00:00 [entrez]
AID - 10.1007/BF02529877 [doi]
PST - ppublish
SO  - Lipids. 1996 Mar;31(3):305-11. doi: 10.1007/BF02529877.