PMID- 8901609
OWN - NLM
STAT- MEDLINE
DCOM- 19961224
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 93
IP  - 22
DP  - 1996 Oct 29
TI  - Cross-talk between the insulin and angiotensin signaling systems.
PG  - 12490-5
AB  - Angiotensin II (AII), acting via its G-protein linked receptor, is an important 
      regulator of cardiac, vascular, and renal function. Following injection of AII 
      into rats, we find that there is also a rapid tyrosine phosphorylation of the 
      major insulin receptor substrates 1 and 2 (IRS-1 and IRS-2) in the heart. This 
      phenomenon appears to involve JAK2 tyrosine kinase, which associates with the AT1 
      receptor and IRS-1/IRS-2 after AII stimulation. AII-induced phosphorylation leads 
      to binding of phosphatidylinositol 3-kinase (PI 3-kinase) to IRS-1 and IRS-2; 
      however, in contrast to other ligands, AII injection results in an acute 
      inhibition of both basal and insulin-stimulated PI 3-kinase activity. The latter 
      occurs without any reduction in insulin receptor or IRS phosphorylation or in the 
      interaction of the p85 and p110 subunits of PI 3-kinase with each other or with 
      IRS-1/IRS-2. These effects of AII are inhibited by AT1 receptor antagonists. 
      Thus, there is direct cross-talk between insulin and AII signaling pathways at 
      the level of both tyrosine phosphorylation and PI 3-kinase activation. These 
      interactions may play an important role in the association of insulin resistance, 
      hypertension, and cardiovascular disease.
FAU - Velloso, L A
AU  - Velloso LA
AD  - Laboratory of Cellular and Molecular Biology, University of Campinas-UNICAMP, 
      Campinas, Brazil.
FAU - Folli, F
AU  - Folli F
FAU - Sun, X J
AU  - Sun XJ
FAU - White, M F
AU  - White MF
FAU - Saad, M J
AU  - Saad MJ
FAU - Kahn, C R
AU  - Kahn CR
LA  - eng
GR  - DK 33201/DK/NIDDK NIH HHS/United States
GR  - DK 38712/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Insulin)
RN  - 0 (Insulin Receptor Substrate Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Irs1 protein, rat)
RN  - 0 (Irs2 protein, rat)
RN  - 0 (Jak3 protein, rat)
RN  - 0 (Phosphoproteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 11128-99-7 (Angiotensin II)
RN  - 42HK56048U (Tyrosine)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - EC 2.7.1.- (Phosphotransferases (Alcohol Group Acceptor))
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.2 (Jak1 protein, rat)
RN  - EC 2.7.10.2 (Jak2 protein, rat)
RN  - EC 2.7.10.2 (Janus Kinase 1)
RN  - EC 2.7.10.2 (Janus Kinase 2)
RN  - EC 2.7.10.2 (Janus Kinase 3)
SB  - IM
MH  - Angiotensin II/*physiology
MH  - Animals
MH  - Electrophoresis, Polyacrylamide Gel
MH  - Insulin/*physiology
MH  - Insulin Receptor Substrate Proteins
MH  - Intracellular Signaling Peptides and Proteins
MH  - Janus Kinase 1
MH  - Janus Kinase 2
MH  - Janus Kinase 3
MH  - Male
MH  - Phosphatidylinositol 3-Kinases
MH  - Phosphoproteins/metabolism
MH  - Phosphorylation
MH  - Phosphotransferases (Alcohol Group Acceptor)/antagonists & inhibitors/metabolism
MH  - Protein-Tyrosine Kinases/metabolism
MH  - *Proto-Oncogene Proteins
MH  - Rats
MH  - Rats, Wistar
MH  - *Signal Transduction
MH  - Tyrosine/metabolism
PMC - PMC38019
EDAT- 1996/10/29 00:00
MHDA- 1996/10/29 00:01
PMCR- 1997/04/29
CRDT- 1996/10/29 00:00
PHST- 1996/10/29 00:00 [pubmed]
PHST- 1996/10/29 00:01 [medline]
PHST- 1996/10/29 00:00 [entrez]
PHST- 1997/04/29 00:00 [pmc-release]
AID - 10.1073/pnas.93.22.12490 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12490-5. doi: 
      10.1073/pnas.93.22.12490.