PMID- 8902581
OWN - NLM
STAT- MEDLINE
DCOM- 19970214
LR  - 20190817
IS  - 0047-1828 (Print)
IS  - 0047-1828 (Linking)
VI  - 60
IP  - 9
DP  - 1996 Sep
TI  - Dipyridamole suppresses catecholamine- and Ca++ influx-sensitive ventricular 
      arrhythmias.
PG  - 629-40
AB  - To study the mechanism of ventricular arrhythmias, the effect of dipyridamole 
      (DIP; 300 mg/day), an adenosine transport inhibitor, on ventricular premature 
      contractions (VPCs) was assessed in 12 patients who showed VPCs (21312 +/- 
      12314/day) on Holter ECG in a controlled setting. The effects were compared with 
      those of verapamil (240 mg/day) and bisoprolol (5 mg/day). DIP suppressed more 
      than one-half the VPCs in 5 patients. The mean degree of reduction in these 
      DIP-responders was 75 +/- 18%. Both verapamil and bisoprolol inhibited VPCs in 
      all of the DIP-responders (verapamil: 71 +/- 15%, bisoprolol: 88 +/- 16%). Two of 
      the 5 DIP-responders had sustained ventricular tachycardias (VT) that were 
      terminated by intravenous DIP, ATP, acetylcholine, verapamil, and propranolol. In 
      contrast, verapamil did not inhibit VPCs in any of the DIP-nonresponders. 
      Bisoprolol also did not suppress VPCs in 3 of 6 DIP-non responders. heart rate 
      was unaffected by DIP, but was suppressed by both verapamil and bisoprolol. In 
      addition, DIP increased the serum concentration of adenosine (control 16.3 +/- 
      17.1 vs 22.3 +/- 19.0 pmol/ml after DIP, p < 0.05). The inhibitory effect of DIP 
      may involve suppression of Ca+2 current through an extracellular increase in 
      adenosine.
FAU - Kobayashi, Y
AU  - Kobayashi Y
AD  - Third Department of Internal Medicine, Showa University School of Medicine, 
      Tokyo, Japan.
FAU - Miyata, A
AU  - Miyata A
FAU - Chiyoda, K
AU  - Chiyoda K
FAU - Nakagawa, H
AU  - Nakagawa H
FAU - Jinbo, Y
AU  - Jinbo Y
FAU - Tanno, K
AU  - Tanno K
FAU - Kikushima, S
AU  - Kikushima S
FAU - Kurano, K
AU  - Kurano K
FAU - Baba, T
AU  - Baba T
FAU - Katagiri, T
AU  - Katagiri T
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Jpn Circ J
JT  - Japanese circulation journal
JID - 7806868
RN  - 0 (Catecholamines)
RN  - 0 (Vasodilator Agents)
RN  - 64ALC7F90C (Dipyridamole)
RN  - CJ0O37KU29 (Verapamil)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biological Transport
MH  - Calcium/*metabolism
MH  - Catecholamines/*metabolism
MH  - Dipyridamole/pharmacology/*therapeutic use
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction/drug effects
MH  - Vasodilator Agents/pharmacology/*therapeutic use
MH  - Ventricular Fibrillation/*drug therapy/metabolism/physiopathology
MH  - Verapamil/pharmacology/therapeutic use
EDAT- 1996/09/01 00:00
MHDA- 1996/09/01 00:01
CRDT- 1996/09/01 00:00
PHST- 1996/09/01 00:00 [pubmed]
PHST- 1996/09/01 00:01 [medline]
PHST- 1996/09/01 00:00 [entrez]
AID - 10.1253/jcj.60.629 [doi]
PST - ppublish
SO  - Jpn Circ J. 1996 Sep;60(9):629-40. doi: 10.1253/jcj.60.629.