PMID- 8905962
OWN - NLM
STAT- MEDLINE
DCOM- 19961217
LR  - 20151008
IS  - 0029-0203 (Print)
IS  - 0029-0203 (Linking)
VI  - 100
IP  - 9
DP  - 1996 Sep
TI  - [The effect of nicardipine on ischemic injury of rabbit retina].
PG  - 665-71
AB  - The effect of nicardipine (NC), a calcium channel blocker, on retinal ischemia 
      was investigated by electroretinogram (ERG). After 0.1 ml of 0.001% (group A), 
      0.01% (group B) or 0.1% (group C) solution of NC or normal saline (control group) 
      was injected into the vitreous body of pigmented rabbits, ischemia was induced by 
      increasing intraocular pressure (IOP) to 140 mm Hg for 60 min by injecting saline 
      into the anterior chamber (n = 4 in each group), then re-perfusion was induced by 
      decreasing the IOP. ERGs (a-, b-, and c-waves) were recorded before the ischemia 
      and immediately, 1, 2, 3, 4, and 24 hours after the re-perfusion. The recovery 
      rate of the ERG b-wave amplitude at 4 hours in groups A, B, C, and the control 
      group was 64.2 +/- 5.4 (mean +/- standard deviation), 104 +/- 16.1, 71.9 +/- 9.1, 
      and 48.1 +/- 6.8% of preischemic amplitudes, respectively. The recovery rate of 
      group B at 4 hours was significantly higher in comparison to groups A and C (p < 
      0.05) and to the control group (p < 0.01). The ERG c-wave in the control group 
      was replaced by a negative wave (PIII) after ischemia for 24 hours, while the 
      c-wave appeared in three eyes out of seven in group B. The results suggest that 
      NC can protect the retina including the retinal pigment epithelium against 
      ischemia.
FAU - Hosobe, Y
AU  - Hosobe Y
AD  - Department of Ophthalmology, Iwate Medical University School of Medicine, 
      Morioka-shi, Japan.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nippon Ganka Gakkai Zasshi
JT  - Nippon Ganka Gakkai zasshi
JID - 7505716
RN  - 0 (Calcium Channel Blockers)
RN  - CZ5312222S (Nicardipine)
SB  - IM
MH  - Animals
MH  - Calcium Channel Blockers/*pharmacology/therapeutic use
MH  - Electroretinography
MH  - Ischemia/*drug therapy
MH  - Nicardipine/*pharmacology/therapeutic use
MH  - Rabbits
MH  - Retinal Vessels/*drug effects
MH  - Vitreous Body/*drug effects
EDAT- 1996/09/01 00:00
MHDA- 1996/09/01 00:01
CRDT- 1996/09/01 00:00
PHST- 1996/09/01 00:00 [pubmed]
PHST- 1996/09/01 00:01 [medline]
PHST- 1996/09/01 00:00 [entrez]
PST - ppublish
SO  - Nippon Ganka Gakkai Zasshi. 1996 Sep;100(9):665-71.