PMID- 8906740
OWN - NLM
STAT- MEDLINE
DCOM- 19970102
LR  - 20190822
IS  - 0090-1229 (Print)
IS  - 0090-1229 (Linking)
VI  - 81
IP  - 2
DP  - 1996 Nov
TI  - Regulation of IgE and cytokine production by cAMP: implications for extrinsic 
      asthma.
PG  - 101-13
AB  - Recent investigations indicate that pharmacologic agents which elevate 
      intracellular levels of cyclic AMP (cAMP) also enhance immunoglobulin E (IgE) 
      production. This review proposes that elevation of intracellular cAMP is a 
      prominent mechanism which enhances IgE production. Enhancement is mediated by two 
      mechanisms. First, cAMP-elevating agents directly target B lymphocytes, promoting 
      recombination of the Ig heavy chain loci. Second, these agents indirectly promote 
      IgE production by inducing a T-helper type 2 (Th2) profile of cytokine secretion. 
      In turn, Th2-type cytokines interact with B lymphocytes and direct isotype 
      switching to the epsilon locus. One type of cAMP-elevating agents, the 
      beta2-adrenergic receptor agonists (beta2-agonists), are used to treat asthma. A 
      number of detrimental phenomena have been associated with beta2-agonist use such 
      as, rebound hyperresponsiveness and increases in asthma mortality. This review 
      theorizes that beta2-agonists enhance IgE and Th2 cytokine production and that 
      these mediators exacerbate extrinsic, IgE-dependent asthma.
FAU - Fedyk, E R
AU  - Fedyk ER
AD  - Immunology Program of the Cancer Center, University of Rochester School of 
      Medicine and Dentistry, New York 14642, USA.
FAU - Adawi, A
AU  - Adawi A
FAU - Looney, R J
AU  - Looney RJ
FAU - Phipps, R P
AU  - Phipps RP
LA  - eng
GR  - CA11198/CA/NCI NIH HHS/United States
GR  - DE11390/DE/NIDCR NIH HHS/United States
GR  - ES01247/ES/NIEHS NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Clin Immunol Immunopathol
JT  - Clinical immunology and immunopathology
JID - 0356637
RN  - 0 (Cytokines)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - E0399OZS9N (Cyclic AMP)
SB  - IM
MH  - Animals
MH  - Asthma/physiopathology
MH  - Cyclic AMP/*pharmacology
MH  - Cytokines/*biosynthesis
MH  - Humans
MH  - Immunoglobulin E/*physiology
RF  - 112
EDAT- 1996/11/01 00:00
MHDA- 1996/11/01 00:01
CRDT- 1996/11/01 00:00
PHST- 1996/11/01 00:00 [pubmed]
PHST- 1996/11/01 00:01 [medline]
PHST- 1996/11/01 00:00 [entrez]
AID - S0090122996901658 [pii]
AID - 10.1006/clin.1996.0165 [doi]
PST - ppublish
SO  - Clin Immunol Immunopathol. 1996 Nov;81(2):101-13. doi: 10.1006/clin.1996.0165.