PMID- 8910910
OWN - NLM
STAT- MEDLINE
DCOM- 19970220
LR  - 20131121
IS  - 0163-5581 (Print)
IS  - 0163-5581 (Linking)
VI  - 26
IP  - 3
DP  - 1996
TI  - Model of mouse mammary gland hyperproliferation and hyperplasia induced by a 
      western-style diet.
PG  - 281-7
AB  - Mammary glands of female C57BL/6J mice were analyzed after they were fed a 
      Western-style diet or control AIN-76A diet. The Western-style diet contained 
      several risk factors found in human diets in geographic regions having increased 
      risk for breast cancer: high fat and phosphate and low calcium and vitamin D. 
      After they were fed these diets for 8, 14, and 20 weeks, mice were sacrificed, 
      and mammary glands were removed for morphometric and radioautographic 
      measurements. Although after the animals were fed the Western-style diet for 8 
      weeks the number of terminal ducts per mouse mammary gland (NTDMG) was similar in 
      the Western-style and control diet groups, after they were fed the Western-style 
      diet for 14 weeks (p < 0.05) and 20 weeks (p < 0.01) the NTDMG significantly 
      increased compared with the control group. Moreover, there was a significant 
      increase (p < 0.01) in the tritiated thymidine labeling index of mammary terminal 
      ductal epithelial cells after 14 and 20 weeks of Western-style diet 
      administration. Thus the Western-style diet induced increased epithelial cell 
      proliferation and increased NTDMG in female mice when fed during young adult 
      growth and development. The findings raise the possibility that the ingestion of 
      a diet with Western-style fat and phosphate content and with low calcium and 
      vitamin D may induce similar changes during the early development of the human 
      mammary gland.
FAU - Xue, L
AU  - Xue L
AD  - Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 
      10021, USA.
FAU - Newmark, H
AU  - Newmark H
FAU - Yang, K
AU  - Yang K
FAU - Lipkin, M
AU  - Lipkin M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Nutr Cancer
JT  - Nutrition and cancer
JID - 7905040
RN  - 0 (Dietary Fats)
RN  - 0 (Phosphates)
RN  - 1406-16-2 (Vitamin D)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Calcium/*administration & dosage
MH  - Cell Division
MH  - *Diet
MH  - Dietary Fats/*administration & dosage
MH  - Disease Models, Animal
MH  - Female
MH  - Humans
MH  - Hyperplasia
MH  - Mammary Glands, Animal/*pathology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Phosphates/*administration & dosage
MH  - Risk Factors
MH  - Vitamin D/*administration & dosage
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1080/01635589609514484 [doi]
PST - ppublish
SO  - Nutr Cancer. 1996;26(3):281-7. doi: 10.1080/01635589609514484.