PMID- 8911926
OWN - NLM
STAT- MEDLINE
DCOM- 19970311
LR  - 20190721
IS  - 0014-4819 (Print)
IS  - 0014-4819 (Linking)
VI  - 111
IP  - 3
DP  - 1996 Oct
TI  - High-frequency vibratory sensitive neurons in monkey primary somatosensory 
      cortex: entrained and nonentrained responses to vibration during the performance 
      of vibratory-cued hand movements.
PG  - 313-25
AB  - The activity of high-frequency vibratory sensitive (HFVS) neurons was recorded in 
      monkey primary somatosensory cortex (SI) while animals performed wrist flexions 
      and extensions in response to 57-Hz or 127-Hz palmar vibration. HFVS neurons were 
      distinguished by their exquisite responsiveness to the higher frequency vibration 
      (127 Hz). These neurons probably received input from Pacinian afferents. 
      Systematic selection of HFVS neurons was made using K-means cluster analysis of 
      neuronal firing rates during stimulating at 127 Hz and 57 Hz. HFVS neurons 
      constituted approximately 4% of all recorded cells and more frequently were found 
      in areas 3b, 1, and 2 (approximately 5% of total in each area) than in area 3a 
      (approximately 1%). Using circular-statistics analyses for nonuniformity of 
      discharges over the vibratory cycle, HFVS neurons were split into two groups of 
      vibration-entrained neurons (E1 and E2 neurons) and one group of nonentrained 
      neurons (NE neurons). E1 neurons were entrained to vibration at both 127 Hz and 
      57 Hz, whereas E2 neurons were entrained only at one of these vibratory 
      frequencies. Vibration-entrained neurons often exhibited multimodal distributions 
      of interspike intervals (ISIs), with the modes at multiples of the period of 
      vibration. In addition, for these neurons, ISI clusters in joint interval plots 
      commonly had diagonal orientations that were indicative of negative serial 
      correlations of the ISIs, a feature of extrinsically driven rhythmic activity. 
      HFVS neurons located in areas 3a, 3b, and 1 responded to vibration onset at 
      shorter latencies (16.5 +/- 1.6, 19.8 +/- 5.9, and 21.4 +/- 6.4 ms, respectively, 
      during 127-Hz stimulation) than those located in area 2 (35.6 +/- 13.8 ms). These 
      observations are consistent with a scheme in which HFVS area 2 neurons receive 
      their inputs from more anterior areas of SI. Moreover, entrained neurons 
      exhibited shorter response latencies than nonentrained neurons. During 127-Hz 
      stimulation, response latencies were 17.3 +/- 3.0, 17.5 +/- 2.6, and 25.7 +/- 6.4 
      ms for E1, E2, and NE neurons, respectively, located in areas 3a, 3b, and 1. 
      Thus, entrained and nonentrained HFVS neurons may belong to different 
      hierarchical stages of information processing.
FAU - Lebedev, M A
AU  - Lebedev MA
AD  - Department of Anatomy and Neurobiology, University of Tennessee, Memphis 38163, 
      USA.
FAU - Nelson, R J
AU  - Nelson RJ
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Germany
TA  - Exp Brain Res
JT  - Experimental brain research
JID - 0043312
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - *Cues
MH  - Evoked Potentials, Somatosensory/*physiology
MH  - Hand
MH  - Macaca mulatta
MH  - Male
MH  - Movement/*physiology
MH  - Neurons/*physiology
MH  - Psychomotor Performance/*physiology
MH  - Reaction Time/physiology
MH  - Somatosensory Cortex/cytology/*physiology
MH  - Touch/physiology
MH  - Vibration
EDAT- 1996/10/01 00:00
MHDA- 1996/10/01 00:01
CRDT- 1996/10/01 00:00
PHST- 1996/10/01 00:00 [pubmed]
PHST- 1996/10/01 00:01 [medline]
PHST- 1996/10/01 00:00 [entrez]
AID - 10.1007/BF00228721 [doi]
PST - ppublish
SO  - Exp Brain Res. 1996 Oct;111(3):313-25. doi: 10.1007/BF00228721.