PMID- 8913288
OWN - NLM
STAT- MEDLINE
DCOM- 19961205
LR  - 20061115
IS  - 0301-472X (Print)
IS  - 0301-472X (Linking)
VI  - 24
IP  - 12
DP  - 1996 Oct
TI  - Stimulation of immune reconstitution by interleukin-7 after syngeneic bone marrow 
      transplantation in mice.
PG  - 1416-22
AB  - Successful outcome of autologous bone marrow transplantation (BMT) is severely 
      handicapped by susceptibility to infection and by a high rate of relapse. While 
      quantitative aspects of the immune system generally return to normal within the 
      first 3-4 months after BMT, the recovery of qualitative immune functions is 
      prolonged. Since interleukin-7 (IL-7) has growth-promoting and differentiating 
      effects on pre-B cells and immature thymocytes, its role in the recovery of 
      immune functions was investigated in BALB/c mice after syngeneic BMT (sBMT). 
      After sBMT, mice treated with human recombinant IL-7 (rIL-7) showed an 11.9-fold 
      increase in thymic cellularity associated with an enhanced response to a 
      mitogenic stimulus compared with the controls. rIL-7 significantly increased 
      RAG-1 expression and promoted V beta 8(D)J gene rearrangement of the T cell 
      receptor in the thymus. Further, the cytokine boosted survival after challenge 
      with influenza virus following sBMT. The finding that rIL-7 induces 
      differentiation and proliferation of immature thymocytes and counteracts post-BMT 
      immune deficiency makes it a promising medium for clinical application in BMT 
      patients.
FAU - Abdul-Hai, A
AU  - Abdul-Hai A
AD  - Department of Bone Marrow Transplantation, Hadassah University Hospital, 
      Jerusalem, Israel.
FAU - Or, R
AU  - Or R
FAU - Slavin, S
AU  - Slavin S
FAU - Friedman, G
AU  - Friedman G
FAU - Weiss, L
AU  - Weiss L
FAU - Matsa, D
AU  - Matsa D
FAU - Ben-Yehuda, A
AU  - Ben-Yehuda A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Exp Hematol
JT  - Experimental hematology
JID - 0402313
RN  - 0 (Interleukin-2)
RN  - 0 (Interleukin-7)
RN  - 0 (Recombinant Proteins)
SB  - IM
EIN - Exp Hematol 1996 Nov;24(13):1540
MH  - Animals
MH  - Bone Marrow Transplantation/*immunology
MH  - Female
MH  - Gene Expression
MH  - Gene Rearrangement, beta-Chain T-Cell Antigen Receptor/drug effects
MH  - Genes, RAG-1/genetics
MH  - Immune System/*drug effects
MH  - Interleukin-2/pharmacology
MH  - Interleukin-7/*pharmacology/therapeutic use
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Orthomyxoviridae Infections/prevention & control
MH  - Recombinant Proteins/pharmacology
MH  - Spleen/immunology
MH  - Thymus Gland/immunology
MH  - Transplantation, Isogeneic
EDAT- 1996/10/01 00:00
MHDA- 1996/10/01 00:01
CRDT- 1996/10/01 00:00
PHST- 1996/10/01 00:00 [pubmed]
PHST- 1996/10/01 00:01 [medline]
PHST- 1996/10/01 00:00 [entrez]
PST - ppublish
SO  - Exp Hematol. 1996 Oct;24(12):1416-22.