PMID- 8914201
OWN - NLM
STAT- MEDLINE
DCOM- 19970218
LR  - 20151119
IS  - 8756-0437 (Print)
IS  - 1098-2388 (Linking)
VI  - 12
IP  - 6
DP  - 1996 Nov-Dec
TI  - Factors associated with melanoma incidence and prognosis.
PG  - 379-85
AB  - Melanoma has a reputation as an unpredictable disease, but investigation has 
      demonstrated a multiplicity of factors which are independently associated with 
      melanoma incidence and prognosis. Major factors associated with melanoma 
      incidence include those related to race and ethnicity, sunlight exposure, and 
      genetic and familial predisposition. Major factors associated with melanoma 
      prognosis include tumor thickness, ulceration, anatomic location, and patient's 
      sex. These factors are clinically important in designing appropriate screening 
      and prevention programs, as well as in selecting appropriate treatment and 
      follow-up for the individual melanoma patient. There is an increasing need to 
      identify the molecular mechanisms underlying these clinically defined etiologic 
      and prognostic factors so that we may treat patients more effectively and more 
      selectively. Available evidence indicates that the mechanisms of melanoma 
      etiology include a loss of tumor suppressor genes. Mechanisms of melanoma 
      progression include the accumulation of oncogene mutations, perhaps as a result 
      of sun exposure, the development of autocrine and paracrine loops involving 
      cytokines and growth factors, and alterations in cell-surface antigen expression. 
      Finally, an antigen-specific immune response to melanoma appears to be important 
      in the prognosis of some patients. Critical regulatory components of the melanoma 
      immune response include antibodies, T-cells, and human leukocyte antigen (HLA) 
      molecules.
FAU - Lee, J E
AU  - Lee JE
AD  - Department of Surgical Oncology, University of Texas M.D. Anderson Cancer Center, 
      Houston 77030, USA.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Semin Surg Oncol
JT  - Seminars in surgical oncology
JID - 8503713
RN  - 0 (Biomarkers)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Biomarkers
MH  - Biomarkers, Tumor
MH  - Female
MH  - Genes, Tumor Suppressor
MH  - Genetic Markers
MH  - Humans
MH  - Male
MH  - Melanoma/*diagnosis/*epidemiology/genetics/immunology
MH  - Mutation
MH  - Neoplasm Metastasis
MH  - Oncogenes/genetics
MH  - Prognosis
MH  - Risk Factors
MH  - Sex Factors
MH  - Sunlight/adverse effects
EDAT- 1996/11/01 00:00
MHDA- 2000/06/22 10:00
CRDT- 1996/11/01 00:00
PHST- 1996/11/01 00:00 [pubmed]
PHST- 2000/06/22 10:00 [medline]
PHST- 1996/11/01 00:00 [entrez]
AID - 10.1002/(SICI)1098-2388(199611/12)12:6<379::AID-SSU2>3.0.CO;2-7 [pii]
AID - 10.1002/(SICI)1098-2388(199611/12)12:6<379::AID-SSU2>3.0.CO;2-7 [doi]
PST - ppublish
SO  - Semin Surg Oncol. 1996 Nov-Dec;12(6):379-85. doi: 
      10.1002/(SICI)1098-2388(199611/12)12:6<379::AID-SSU2>3.0.CO;2-7.