PMID- 8916448
OWN - NLM
STAT- MEDLINE
DCOM- 19961223
LR  - 20041117
IS  - 0034-8376 (Print)
IS  - 0034-8376 (Linking)
VI  - 48
IP  - 4
DP  - 1996 Jul-Aug
TI  - Diagnostic concordance in biopsies of deceptive prostatic carcinoma.
PG  - 289-96
AB  - OBJECTIVE: To explore the diagnostic concordancy of surgery pathologists in 
      deceptive prostatic carcinoma biopsies (DPCs) purposely selected as of difficult 
      interpretation. SETTING: Ten experienced pathologists belonging to five tertiary 
      care centers in Mexico City participated. MATERIAL AND METHODS: A total of 25 
      slides (16 DPCs and 9 benign biopsies) were marked and circulated among the 
      participants. They were asked to classify each slide in one of five categories 
      ranging from carcinoma to benign hyperplasia using the criteria of Epstein. The 
      16 DPCs had been confirmed by immunohistochemistry studies and by review of two 
      expert uropathologists from the MD Anderson Medical Center in Houston TX. A 
      weighted kappa was use to evaluate the concordancy of the pathologists. RESULTS: 
      The concordancy with the experts opinion ranged from substantial in one 
      pathologist (KW = 0.77) to bad in another (KW = -0.07) and the mean kappa was 
      0.32. In two of the three institutions with more than one pathologist, the 
      intrainstitucional concordancy improved (KW of 0.57-0.64). The pathologists were 
      unable to reach a consensus (7 or more agreeing) in 12 of the 25 slides. Overall, 
      12% of the diagnosis were considered uncertain, 29% were incorrect (45% of DPCs 
      and 19% of benign) and only 59% were correct (55% of DPCs and 67% of benign). 
      CONCLUSION: Efforts should be made to improve the diagnostic accuracy of 
      pathologists in DPCs.
FAU - Arista-Nasr, J
AU  - Arista-Nasr J
AD  - Dpto de Patologia, Instituto Nacional de la Nutricion Salvador Zubiran, Mexico 
      City.
FAU - Cortes, E
AU  - Cortes E
FAU - Keirns, C
AU  - Keirns C
FAU - Hatchett, A
AU  - Hatchett A
FAU - Loria, A
AU  - Loria A
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - Mexico
TA  - Rev Invest Clin
JT  - Revista de investigacion clinica; organo del Hospital de Enfermedades de la 
      Nutricion
JID - 9421552
SB  - IM
MH  - Adenocarcinoma/*pathology
MH  - Adenocarcinoma, Clear Cell/pathology
MH  - Biopsy
MH  - Humans
MH  - Male
MH  - Observer Variation
MH  - Prostate/*pathology
MH  - Prostatic Hyperplasia/*pathology
MH  - Prostatic Neoplasms/*pathology
EDAT- 1996/07/01 00:00
MHDA- 1996/07/01 00:01
CRDT- 1996/07/01 00:00
PHST- 1996/07/01 00:00 [pubmed]
PHST- 1996/07/01 00:01 [medline]
PHST- 1996/07/01 00:00 [entrez]
PST - ppublish
SO  - Rev Invest Clin. 1996 Jul-Aug;48(4):289-96.