PMID- 8920681
OWN - NLM
STAT- MEDLINE
DCOM- 19961231
LR  - 20181130
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 54
IP  - 4
DP  - 1996 Apr
TI  - [Cholecystokinin and cholecystokinin receptor].
PG  - 1097-1103
AB  - Cholecystokinin (CCK) act as hormones and neuropeptides on central and peripheral 
      CCK receptors. The application of modern molecular biological techniques has 
      identified two CCK receptors, CCK-A receptor (CCKAR) and CCK-B/gastrin receptor 
      (CCKBR). The genes of CCKAR and CCKBR consist of five exons interrupted by four 
      introns. We have reported that OLETF rats, which have been established as an 
      animal model of NIDDM, revealed no expression of CCKAR gene (a naturally 
      occurring CCKAR gene knockout rat). Pancreatic exocrine functions in OLETF rats 
      are regulated by all neural and peptidergic agents except CCK. Therefore, we have 
      proposed that OLETF rats may be a useful experimental model for examining the 
      biological functions of the CCKAR.
FAU - Funakoshi, A
AU  - Funakoshi A
AD  - Department of Gastroenterology, National Kyushu Cancer Center.
LA  - jpn
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
RN  - 0 (Receptor, Cholecystokinin A)
RN  - 0 (Receptor, Cholecystokinin B)
RN  - 0 (Receptors, Cholecystokinin)
RN  - 9011-97-6 (Cholecystokinin)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - *Cholecystokinin/genetics/physiology
MH  - Cloning, Molecular
MH  - Diabetes Mellitus, Type 2
MH  - Disease Models, Animal
MH  - Humans
MH  - Molecular Sequence Data
MH  - Pancreas/metabolism
MH  - Receptor, Cholecystokinin A
MH  - Receptor, Cholecystokinin B
MH  - *Receptors, Cholecystokinin/genetics/physiology
RF  - 20
EDAT- 1996/04/01 00:00
MHDA- 1996/04/01 00:01
CRDT- 1996/04/01 00:00
PHST- 1996/04/01 00:00 [pubmed]
PHST- 1996/04/01 00:01 [medline]
PHST- 1996/04/01 00:00 [entrez]
PST - ppublish
SO  - Nihon Rinsho. 1996 Apr;54(4):1097-1103.