PMID- 8922146
OWN - NLM
STAT- MEDLINE
DCOM- 19970213
LR  - 20190606
IS  - 1088-5412 (Print)
IS  - 1088-5412 (Linking)
VI  - 17
IP  - 5
DP  - 1996 Sep-Oct
TI  - Nasal polyps and immunoglobulin E (IgE).
PG  - 269-73
AB  - Nasal polyps are usually found in nonallergic individuals. However, when nasal 
      polyps and atopy occur together, a special interaction exists. Total and specific 
      immunoglobulin E (IgE) are found in significantly greater concentration in nasal 
      polyp tissue than in serum and tonsil tissue. Immunoglobulin A (IgA) is also more 
      concentrated in nasal polyps than serum. Patients with nasal polyps and allergies 
      seem to have a greater recurrence rate after surgical polypectomy. Frequently, 
      polyp recurrence occurs during specific pollen seasons in sensitive individuals. 
      Upper respiratory infections are also a precipitating factor for recurrence. 
      Nasal ciliary beat frequency is inhibited in patients with chronic sinusitis, 
      allergic nasal reactions, and nonspecific nasal eosinophilia syndromes: 
      nonallergic rhinitis with eosinophils (NARES) and blood eosinophilic nonallergic 
      rhinitis (BENARS). Nasal polyps are frequently associated with these conditions, 
      which may predispose the nasal mucosa to infections and increased risk for 
      developing nasal polyps. When nasal polyps and allergies occur together, it is 
      important to treat the allergic condition. This takes the form of identifying the 
      allergens, eliminating them from the environment (if possible) using 
      antihistamines/decongestants, and nasal antiinflammatory drugs such as topical 
      steroids. Hyposensitization may be considered in resistant cases.
FAU - Settipane, G A
AU  - Settipane GA
AD  - Brown University School of Medicine, Providence, Rhode Island, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Immunoglobulin A)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Humans
MH  - Hypersensitivity/complications/diagnosis/therapy
MH  - Immunoglobulin A/analysis/immunology
MH  - Immunoglobulin E/analysis/*immunology
MH  - Nasal Polyps/*immunology/surgery
MH  - Recurrence
RF  - 28
EDAT- 1996/09/01 00:00
MHDA- 1996/09/01 00:01
CRDT- 1996/09/01 00:00
PHST- 1996/09/01 00:00 [pubmed]
PHST- 1996/09/01 00:01 [medline]
PHST- 1996/09/01 00:00 [entrez]
AID - 10.2500/108854196778662237 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 1996 Sep-Oct;17(5):269-73. doi: 10.2500/108854196778662237.