PMID- 8922294
OWN - NLM
STAT- MEDLINE
DCOM- 19970211
LR  - 20221207
IS  - 1055-9965 (Print)
IS  - 1055-9965 (Linking)
VI  - 5
IP  - 11
DP  - 1996 Nov
TI  - Distribution of human leukocyte antigens in a population of black patients with 
      human T-cell lymphotrophic virus type I-associated adult T-cell 
      leukemia/lymphoma.
PG  - 873-7
AB  - Human leukocyte antigens (HLAs) play an important role in regulating the immune 
      response to infectious agents and determinants of malignant transformation. We 
      compared the HLA frequencies of 25 black patients with adult T-cell 
      leukemia/lymphoma (ATL) referred to the National Cancer Institute for therapy 
      with a racially similar, asymptomatic control population of human T-cell 
      lymphotrophic virus, type I (HTLV-I)-seropositive individuals (n = 45). 
      Serological typing was performed for MHC class I and II antigens. Antigen 
      frequencies were calculated, and corresponding gene frequencies were estimated 
      using the maximum likelihood method. Comparisons between the ATL and control 
      group were made with chi 2 or Fisher's exact test. Three antigens (A36, B18, and 
      DR53) were found to have a higher frequency in the ATL patients than in the 
      controls (uncorrected two-tailed P < 0.05). The gene frequencies for these 
      antigens also were statistically significant in the uncorrected analysis. 
      However, only A36 approached statistical significance after correction of the P 
      value for multiple comparisons (P = 0.08). The results of this pilot study 
      indicate that black patients with ATL may have increased frequencies of certain 
      class I HLA when compared with a racially similar HTLV-I-positive reference 
      population. This suggests that either these antigens may represent markers for a 
      population at greater risk of developing ATL once infected with HTLV-I or that 
      they were acquired at some point in the process of malignant transformation or 
      progression from the carrier state to onset of ATL. These antigens should be 
      targeted in larger studies to confirm or refute these findings.
FAU - White, J D
AU  - White JD
AD  - Metabolism Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.
FAU - Johnson, J A
AU  - Johnson JA
FAU - Nam, J M
AU  - Nam JM
FAU - Cranston, B
AU  - Cranston B
FAU - Hanchard, B
AU  - Hanchard B
FAU - Waldmann, T A
AU  - Waldmann TA
FAU - Manns, A
AU  - Manns A
LA  - eng
GR  - N01-CP-31006/CP/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer Epidemiol Biomarkers Prev
JT  - Cancer epidemiology, biomarkers & prevention : a publication of the American 
      Association for Cancer Research, cosponsored by the American Society of 
      Preventive Oncology
JID - 9200608
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Black People/*genetics
MH  - Female
MH  - Gene Frequency
MH  - HLA Antigens/*analysis/genetics
MH  - HTLV-I Infections/complications/genetics/*immunology
MH  - Humans
MH  - Leukemia, T-Cell/epidemiology/genetics/*immunology/virology
MH  - Likelihood Functions
MH  - Lymphoma, T-Cell/epidemiology/genetics/*immunology/virology
MH  - Major Histocompatibility Complex/genetics/*immunology
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Survival Analysis
EDAT- 1996/11/01 00:00
MHDA- 1996/11/01 00:01
CRDT- 1996/11/01 00:00
PHST- 1996/11/01 00:00 [pubmed]
PHST- 1996/11/01 00:01 [medline]
PHST- 1996/11/01 00:00 [entrez]
PST - ppublish
SO  - Cancer Epidemiol Biomarkers Prev. 1996 Nov;5(11):873-7.