PMID- 8923507
OWN - NLM
STAT- MEDLINE
DCOM- 19970328
LR  - 20190914
IS  - 0143-4179 (Print)
IS  - 0143-4179 (Linking)
VI  - 30
IP  - 5
DP  - 1996 Oct
TI  - Effect of central administration of the kappa-opiate receptor agonist U 69.593 on 
      neurohypophyseal hormone levels in blood and cerebrospinal fluid.
PG  - 452-5
AB  - Intracerebroventricular (i.c.v.) administration of the kappa-opiate receptor 
      agonist U 69.593 induces a rapid and short lasting suppression of oxytocin (OXT) 
      levels in plasma of water deprived rats, whereas only a tendency towards a 
      suppression of vasopressin (AVP) levels in plasma is observed. No change in 
      neurohypophyseal hormone levels in CSF occurs following i.c.v. administration of 
      U 69.593 at the various times points studied. It is concluded that, upon i.c.v. 
      administration, the suppressive influence of U 69.593 is much weaker than that of 
      the dynorphins and that neurophypophyseal hormone levels in CSF behave 
      differently from those in the peripheral circulation.
FAU - van Wimersma Greidanus, T B
AU  - van Wimersma Greidanus TB
AD  - Rudolf Magnus Institute for Neurosciences, Department of Pharmacology, 
      Universiteitsweg, Utrecht, The Netherlands.
FAU - Janssen, S
AU  - Janssen S
FAU - Frankhuijzen-Sierevogel, J C
AU  - Frankhuijzen-Sierevogel JC
FAU - Maigret, C
AU  - Maigret C
FAU - van de Heijning, B J
AU  - van de Heijning BJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Neuropeptides
JT  - Neuropeptides
JID - 8103156
RN  - 0 (Analgesics)
RN  - 0 (Benzeneacetamides)
RN  - 0 (Pyrrolidines)
RN  - 0 (Receptors, Opioid, kappa)
RN  - 113-79-1 (Arginine Vasopressin)
RN  - 50-56-6 (Oxytocin)
RN  - 60617-12-1 (beta-Endorphin)
RN  - 74913-18-1 (Dynorphins)
RN  - J5S4K6TKTG (U 69593)
SB  - IM
MH  - Analgesics/administration & dosage/*pharmacology
MH  - Animals
MH  - Arginine Vasopressin/blood/cerebrospinal fluid/*metabolism
MH  - *Benzeneacetamides
MH  - Depression, Chemical
MH  - Dynorphins/pharmacology
MH  - Male
MH  - Oxytocin/blood/cerebrospinal fluid/*metabolism
MH  - Pituitary Gland, Posterior/*drug effects/metabolism
MH  - Pyrrolidines/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Opioid, kappa/*agonists
MH  - Water Deprivation/physiology
MH  - beta-Endorphin/pharmacology
EDAT- 1996/10/01 00:00
MHDA- 1996/10/01 00:01
CRDT- 1996/10/01 00:00
PHST- 1996/10/01 00:00 [pubmed]
PHST- 1996/10/01 00:01 [medline]
PHST- 1996/10/01 00:00 [entrez]
AID - S0143-4179(96)90009-8 [pii]
AID - 10.1016/s0143-4179(96)90009-8 [doi]
PST - ppublish
SO  - Neuropeptides. 1996 Oct;30(5):452-5. doi: 10.1016/s0143-4179(96)90009-8.