PMID- 8924212
OWN - NLM
STAT- MEDLINE
DCOM- 19961127
LR  - 20171116
IS  - 1044-5498 (Print)
IS  - 1044-5498 (Linking)
VI  - 15
IP  - 5
DP  - 1996 May
TI  - Genomic organization and chromosomal mapping of the bovine Fas/APO-1 gene.
PG  - 377-85
AB  - The cell-surface protein Fas (APO-1) is a member of the tumor necrosis factor 
      receptor (TNFR) superfamily and transduces apoptosis following binding of Fas 
      ligand or exposure to certain anti-Fas antibodies. We have isolated the bovine 
      Fas (bFas) gene and determined its genomic organization and chromosomal location. 
      Our data indicate that bFas is a single-copy gene that contains 9 exons and spans 
      approximately 31.5 kb. The 5'-flanking region lacks conventional TATA and CCAAT 
      elements, but contains several putative regulatory elements, including multiple 
      copies of Sp1, AP-2, E-box, and N-box consensus sites. Linkage analysis of two 
      (CA) dinucleotide repeat microsatellites within intron 1 and physical assignment 
      by fluorescence in situ hybridization (FISH) placed the bFas gene on bovine 
      chromosome 26. Collectively, these data provide a basis for understanding the 
      regulatory mechanisms that control bFas gene expression.
FAU - Yoo, J
AU  - Yoo J
AD  - USDA, ARS, Roman L. Hruska U.S. Meat Animal Research Center (MARC), Clay Center, 
      NE 68933, USA.
FAU - Stone, R T
AU  - Stone RT
FAU - Kappes, S M
AU  - Kappes SM
FAU - Toldo, S S
AU  - Toldo SS
FAU - Fries, R
AU  - Fries R
FAU - Beattie, C W
AU  - Beattie CW
LA  - eng
SI  - GENBANK/U24240
SI  - GENBANK/U24439
SI  - GENBANK/U24440
PT  - Journal Article
PL  - United States
TA  - DNA Cell Biol
JT  - DNA and cell biology
JID - 9004522
RN  - 0 (fas Receptor)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Cattle
MH  - *Chromosome Mapping
MH  - Cloning, Molecular
MH  - DNA/analysis
MH  - Dinucleotide Repeats/genetics
MH  - Exons/genetics
MH  - Gene Dosage
MH  - Genes/*genetics
MH  - Genetic Linkage
MH  - In Situ Hybridization, Fluorescence
MH  - Introns/genetics
MH  - Molecular Sequence Data
MH  - Sequence Analysis, DNA
MH  - Transcription, Genetic/genetics
MH  - fas Receptor/*genetics
EDAT- 1996/05/01 00:00
MHDA- 1996/05/01 00:01
CRDT- 1996/05/01 00:00
PHST- 1996/05/01 00:00 [pubmed]
PHST- 1996/05/01 00:01 [medline]
PHST- 1996/05/01 00:00 [entrez]
AID - 10.1089/dna.1996.15.377 [doi]
PST - ppublish
SO  - DNA Cell Biol. 1996 May;15(5):377-85. doi: 10.1089/dna.1996.15.377.