PMID- 8929443
OWN - NLM
STAT- MEDLINE
DCOM- 19961219
LR  - 20191101
IS  - 0270-6474 (Print)
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 16
IP  - 22
DP  - 1996 Nov 15
TI  - Enhanced amphetamine sensitivity and increased expression of dopamine D2 
      receptors in postpubertal rats after neonatal excitotoxic lesions of the medial 
      prefrontal cortex.
PG  - 7366-75
AB  - Functional and structural abnormalities in the medial prefrontal cortex (MPFC) 
      and overactive dopamine (DA) neurotransmission are thought to be the key 
      pathologies in schizophrenia. To understand the role of MPFC in the pre- and 
      postpubertal development of the subcortical DA system, the effects of neonatal 
      [postnatal day 7 (PD7)] MPFC excitotoxic lesions on locomotor behaviors and the 
      expression of DA receptor subtypes and DA transporter were investigated in 
      Sprague Dawley rats at PD35 and PD56, respectively. No significant differences in 
      the novelty of d-amphetamine-induced locomotion were observed between 
      sham-operated and ibotenic acid-lesioned rats at PD35. Postpubertally (at PD56), 
      however, the locomotor activity of lesioned rats in the novel environment and 
      after d-amphetamine administration was enhanced significantly compared with 
      controls. The expressions of DA D1, D2, D3, and D4 receptors and DA transporter 
      were then estimated in MPFC-lesioned and sham-operated rats at PD59 and PD60. The 
      levels of DA D2 receptors, measured using [3H]-YM-09151-2 binding, and its mRNA 
      by in situ hybridization, were observed to be significantly increased at PD60 in 
      striatal and limbic areas of lesioned rats. Levels of other DA receptor subtypes 
      were not significantly affected at any time points. Lesioned rats at PD39 show a 
      small increase in DA transporter level in the shell of nucleus accumbens; 
      however, this effect seems to wear off at PD60. The data suggest that neonatal 
      MPFC lesions may alter the functional development and maturation of 
      mesolimbic/nigrostriatal DA systems in that neonatally lesioned rats grow into a 
      behavioral/neurochemical deficit.
FAU - Flores, G
AU  - Flores G
AD  - Douglas Hospital Research Center, Department of Psychiatry, McGill University, 
      Montreal, Quebec, Canada.
FAU - Wood, G K
AU  - Wood GK
FAU - Liang, J J
AU  - Liang JJ
FAU - Quirion, R
AU  - Quirion R
FAU - Srivastava, L K
AU  - Srivastava LK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Benzamides)
RN  - 0 (Benzazepines)
RN  - 0 (Carrier Proteins)
RN  - 0 (Dopamine Agents)
RN  - 0 (Dopamine Agonists)
RN  - 0 (Dopamine Antagonists)
RN  - 0 (Dopamine Plasma Membrane Transport Proteins)
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurotoxins)
RN  - 0 (Receptors, Dopamine D2)
RN  - 0 (Tetrahydronaphthalenes)
RN  - 10028-17-8 (Tritium)
RN  - 50370-56-4 ((1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- 
      azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester)
RN  - CK833KGX7E (Amphetamine)
RN  - I5Y540LHVR (Cocaine)
RN  - Q88T5P3444 (nemonapride)
RN  - RR7D75YDF4 (7-hydroxy-2-N,N-dipropylaminotetralin)
SB  - IM
MH  - Amphetamine/*pharmacology
MH  - Animals
MH  - Animals, Newborn
MH  - Behavior, Animal/drug effects
MH  - Benzamides/metabolism/pharmacology
MH  - Benzazepines/metabolism/pharmacology
MH  - Binding, Competitive/physiology
MH  - Carrier Proteins/metabolism
MH  - Cocaine/analogs & derivatives/metabolism/pharmacology
MH  - Dopamine Agents/*pharmacology
MH  - Dopamine Agonists/metabolism/pharmacology
MH  - Dopamine Antagonists/metabolism/pharmacology
MH  - Dopamine Plasma Membrane Transport Proteins
MH  - Dopamine Uptake Inhibitors/metabolism/pharmacology
MH  - Female
MH  - In Situ Hybridization
MH  - Locomotion/drug effects
MH  - *Membrane Glycoproteins
MH  - *Membrane Transport Proteins
MH  - *Nerve Tissue Proteins
MH  - Neurotoxins
MH  - Prefrontal Cortex/chemistry/*drug effects/surgery
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Dopamine D2/genetics/*metabolism
MH  - Sensitivity and Specificity
MH  - Sexual Maturation/physiology
MH  - Tetrahydronaphthalenes/metabolism/pharmacology
MH  - Tritium
PMC - PMC6578944
EDAT- 1996/11/15 00:00
MHDA- 1996/11/15 00:01
PMCR- 1997/05/15
CRDT- 1996/11/15 00:00
PHST- 1996/11/15 00:00 [pubmed]
PHST- 1996/11/15 00:01 [medline]
PHST- 1996/11/15 00:00 [entrez]
PHST- 1997/05/15 00:00 [pmc-release]
AID - 10.1523/JNEUROSCI.16-22-07366.1996 [doi]
PST - ppublish
SO  - J Neurosci. 1996 Nov 15;16(22):7366-75. doi: 10.1523/JNEUROSCI.16-22-07366.1996.