PMID- 8929971
OWN - NLM
STAT- MEDLINE
DCOM- 19970117
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 204
IP  - 1-2
DP  - 1996 Feb 2
TI  - Studies of synaptic transmission in vivo: indirect versus direct effects of 
      (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid/kainate 
      antagonists on rat spinal sensory responses.
PG  - 33-6
AB  - The (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA)/kainate 
      receptor antagonists 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]quinoxaline (NBQX) 
      and 6-cyano-7-nitro-quinoxaline-2,3-dione (CNQX) were examined by 
      microiontophoretic administration in electrophysiological tests on spinal 
      neurones in alpha-chloralose anaesthetized rats. The antagonists significantly 
      reduced extracellularly recorded nociceptive and non-nociceptive responses, as 
      expected; concurrently they reduced background discharge. When the background 
      discharge rate was held constant, the antagonists no longer significantly reduced 
      the evoked responses. This indicates that in the absence of such control, the 
      antagonists decreased cell excitability and only indirectly affected the test 
      responses. Unless such indirect effects have been controlled for, the 
      interpretation of the actions of AMPA/kainate antagonists on evoked synaptic 
      responses is compromised and may be erroneous.
FAU - Cumberbatch, M J
AU  - Cumberbatch MJ
AD  - Department of Physiology, School of Medical Sciences, University of Bristol, UK.
FAU - Herrero, J F
AU  - Herrero JF
FAU - Headley, P M
AU  - Headley PM
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Excitatory Amino Acid Agonists)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Quinoxalines)
RN  - 0 (Receptors, AMPA)
RN  - 0 (Receptors, Kainic Acid)
RN  - 118876-58-7 (2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 6OTE87SCCW (6-Cyano-7-nitroquinoxaline-2,3-dione)
SB  - IM
MH  - 6-Cyano-7-nitroquinoxaline-2,3-dione/pharmacology
MH  - Animals
MH  - Evoked Potentials/drug effects/physiology
MH  - Excitatory Amino Acid Agonists/pharmacology
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Extracellular Space/drug effects/physiology
MH  - Iontophoresis
MH  - Male
MH  - Microelectrodes
MH  - N-Methylaspartate/pharmacology
MH  - Neurons, Afferent/*physiology
MH  - Nociceptors/drug effects/physiology
MH  - Quinoxalines/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, AMPA/*antagonists & inhibitors
MH  - Receptors, Kainic Acid/*antagonists & inhibitors
MH  - Spinal Cord/cytology/*physiology
MH  - Synaptic Transmission/*physiology
EDAT- 1996/02/02 00:00
MHDA- 1996/02/02 00:01
CRDT- 1996/02/02 00:00
PHST- 1996/02/02 00:00 [pubmed]
PHST- 1996/02/02 00:01 [medline]
PHST- 1996/02/02 00:00 [entrez]
AID - 0304-3940(96)12309-0 [pii]
AID - 10.1016/0304-3940(96)12309-0 [doi]
PST - ppublish
SO  - Neurosci Lett. 1996 Feb 2;204(1-2):33-6. doi: 10.1016/0304-3940(96)12309-0.