PMID- 8930933
OWN - NLM
STAT- MEDLINE
DCOM- 19970220
LR  - 20181130
IS  - 0028-3835 (Print)
IS  - 0028-3835 (Linking)
VI  - 64
IP  - 5
DP  - 1996 Nov
TI  - Interactions of histaminergic and serotonergic neurons in the hypothalamic 
      regulation of prolactin and ACTH secretion.
PG  - 329-36
AB  - Serotonergic and histaminergic neuronal systems are both involved in mediation of 
      the stress-induced release of the pituitary hormones prolactin (PRL) and ACTH. We 
      investigated the possibility of an interaction between serotonin (5-HT) and 
      histamine (HA) in regulation of PRL and ACTH secretion in conscious male rats. 
      Animals were pretreated systemically with antagonists to 5-HT1, 5-HT2 or 5-HT3 
      receptors prior to intracerebroventricular (icv) administration of HA. The 5-HT1 
      + 2 receptor antagonist methysergide prevented and the 5-HT2 receptor antagonist 
      LY 53857 attenuated the HA-induced PRL release while the 5-HT3 receptor 
      antagonist ondansetron had no effect on this response. None of the three 5-HT 
      receptor antagonists affected the ACTH response to HA. Specific blockade of HA 
      synthesis by alpha-fluoromethylhistidine or blockade of postsynaptic HA receptors 
      by icv infusion of the H1 receptor antagonist mepyramine or the H2 receptor 
      antagonist cimetidine inhibited the PRL response to 5-HT or to the 5-HT precursor 
      5-hydroxytryptophan (5- HTP) given in combination with the 5-HT reuptake 
      inhibitor fluoxetine (Flx). Blockade of the histaminergic system had no effect on 
      the ACTH response to serotonergic stimulation. The H3 receptors are inhibitory HA 
      receptors. Systemic pretreatment with the H3 receptor agonist 
      R(alpha)methylhistamine, or the H3 receptor antagonist thioperamide had no effect 
      on the hormone response to activation of the serotonergic system by 5-HTP plus 
      Flx. We conclude that the serotonergic and histaminergic neuronal systems 
      interact in their stimulation of PRL secretion, but not in their stimulation of 
      ACTH secretion. This interaction involves serotonergic 5-HT1 and 5-HT2 receptors 
      and histaminergic H1 and H2 receptors. Furthermore, the previously observed 
      inhibitory effect of the H3 receptor agonist R(alpha)methylhistamine on 
      stress-induced PRL and ACTH release seems not to be exerted by activation of 
      presynaptic H3 receptors located on serotonergic neurons but rather on 
      histaminergic neurons.
FAU - Jorgensen, H
AU  - Jorgensen H
AD  - Department of Medical Physiology, Panum-Institute, University of Copenhagen, 
      Denmark.
FAU - Knigge, U
AU  - Knigge U
FAU - Kjaer, A
AU  - Kjaer A
FAU - Warberg, J
AU  - Warberg J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - 0 (Histamine Antagonists)
RN  - 0 (Serotonin Antagonists)
RN  - 01K63SUP8D (Fluoxetine)
RN  - 333DO1RDJY (Serotonin)
RN  - 820484N8I3 (Histamine)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - 9002-62-4 (Prolactin)
RN  - C1LJO185Q9 (5-Hydroxytryptophan)
SB  - IM
MH  - 5-Hydroxytryptophan/pharmacology
MH  - Adrenocorticotropic Hormone/*metabolism
MH  - Animals
MH  - Fluoxetine/pharmacology
MH  - Histamine/administration & dosage/*metabolism/pharmacology
MH  - Histamine Antagonists/pharmacology
MH  - Hypothalamus/*physiology
MH  - Injections, Intraventricular
MH  - Male
MH  - Neurons/*physiology
MH  - Prolactin/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Serotonin/*metabolism/pharmacology
MH  - Serotonin Antagonists/pharmacology
EDAT- 1996/11/01 00:00
MHDA- 1996/11/01 00:01
CRDT- 1996/11/01 00:00
PHST- 1996/11/01 00:00 [pubmed]
PHST- 1996/11/01 00:01 [medline]
PHST- 1996/11/01 00:00 [entrez]
AID - 10.1159/000127136 [doi]
PST - ppublish
SO  - Neuroendocrinology. 1996 Nov;64(5):329-36. doi: 10.1159/000127136.