PMID- 8931216
OWN - NLM
STAT- MEDLINE
DCOM- 19970304
LR  - 20190920
IS  - 0941-1291 (Print)
IS  - 0941-1291 (Linking)
VI  - 26
IP  - 11
DP  - 1996
TI  - Numerical aberrations of chromosomes 11 and 17 in colorectal adenocarcinomas.
PG  - 869-74
AB  - Fluorescence in situ hybridization (FISH) is an easy and efficient means of 
      measuring numerical chromosome aberrations in the interphase nuclei of solid 
      tumors; however, the correlation between numerical chromosome aberrations and the 
      clinical stage of solid tumors remains unknown. Thus, in the present study, we 
      investigated the relationship between numerical chromosome aberrations and 
      clinicopathologic features in colorectal adenocarcinomas. FISH was applied to 
      surgically resected colorectal cancer samples from 45 patients to evaluate the 
      numerical aberrations of chromosomes 11 and 17. The mean age of the patients was 
      65.1 years, and they comprised 13 women and 32 men. According to Dukes' 
      classification, 5 patients were categorized as stage A, 21 as stage B, 10 as 
      stage C, and 9 as stage D. Histologically, 18 of the samples were lymph node 
      metastasis-positive. FISH revealed numerical aberrations of chromosome 11 in 27 
      out of the 45 patients (60%), and those with a lower chromosome 11 number had a 
      significantly lower incidence of lymph node metastasis (P < 0.05). Chromosome 17 
      proved to have numerical abnormalities in 33 of the 45 patients (73%), and those 
      with a higher chromosome 17 number had more DNA aneuploidy (P < 0.005). This is 
      the first report to reveal the relationship between monosomy 11 and lymph node 
      metastasis in colorectal adenocarcinomas.
FAU - Tagawa, Y
AU  - Tagawa Y
AD  - First Department of Surgery, Nagasaki University School of Medicine, Japan.
FAU - Sawai, T
AU  - Sawai T
FAU - Nakagoe, T
AU  - Nakagoe T
FAU - Morinaga, M
AU  - Morinaga M
FAU - Yasutake, T
AU  - Yasutake T
FAU - Ayabe, H
AU  - Ayabe H
FAU - Tomita, M
AU  - Tomita M
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Surg Today
JT  - Surgery today
JID - 9204360
RN  - 0 (DNA, Neoplasm)
SB  - IM
MH  - Adenocarcinoma/*genetics/pathology
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aneuploidy
MH  - *Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 11
MH  - *Chromosomes, Human, Pair 17
MH  - Colorectal Neoplasms/*genetics/pathology
MH  - DNA, Neoplasm/genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphatic Metastasis/genetics
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1007/BF00311787 [doi]
PST - ppublish
SO  - Surg Today. 1996;26(11):869-74. doi: 10.1007/BF00311787.