PMID- 893296
OWN - NLM
STAT- MEDLINE
DCOM- 19771028
LR  - 20171213
IS  - 0161-7567 (Print)
IS  - 0161-7567 (Linking)
VI  - 43
IP  - 2
DP  - 1977 Aug
TI  - Hematologic responses to carbon monoxide and altitude: a comparative study.
PG  - 365-9
AB  - Groups of 40- and 90-day-old rats were exposed to 500 ppm CO (HbCO=31-43%) and 
      simulated altitude (15,000 ft). Resulting hematologic changes were monitored 
      after 1 day, 1 wk, 3-4 wk, and 9-11 wk of exposure. The two treatments resulted 
      in similar changes in hemoglobin (Hb) and hematocrit ratio (Hct) in the young 
      rats, while in the older group there were several small, but significant 
      differences in these parameters. Mean corpuscular hemoglobin concentration (MCHC) 
      fell 12.4-15.1% during the 1st wk of exposure in all groups except the young 
      altitude rats, which remained at the control value. The former groups returned to 
      control levels by the 3rd to 4th wk of exposure. Red cell 2,3-diphosphoglycerate 
      (2,3-DPG) increased 21.6-26.1% above control during 3-4 wk of altitude exposure, 
      but later (9-11 wk) returned toward control levels. CO exposure resulted in a 
      sharp decrease in 2,3-DPG after 1 day of exposure only in the young rats. 2,3-DPG 
      level progressively decreased with age in control rats. The effects of CO and 
      altitude although similar in several respects (i.e., Hb, Hct, MCHC) differ with 
      regard to red cell 2,3-DPG.
FAU - Thomas, M F
AU  - Thomas MF
FAU - Penney, D G
AU  - Penney DG
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Appl Physiol Respir Environ Exerc Physiol
JT  - Journal of applied physiology: respiratory, environmental and exercise physiology
JID - 7801242
RN  - 0 (Diphosphoglyceric Acids)
RN  - 0 (Hemoglobins)
RN  - 7U1EE4V452 (Carbon Monoxide)
SB  - IM
MH  - Adaptation, Physiological
MH  - Aging
MH  - *Altitude
MH  - Animals
MH  - Atmosphere Exposure Chambers
MH  - *Blood
MH  - *Carbon Monoxide
MH  - Diphosphoglyceric Acids/blood
MH  - Hematocrit
MH  - Hemoglobins
MH  - Male
MH  - Rats
MH  - Stress, Physiological
OID - NASA: 77249263
EDAT- 1977/08/01 00:00
MHDA- 1977/08/01 00:01
CRDT- 1977/08/01 00:00
PHST- 1977/08/01 00:00 [pubmed]
PHST- 1977/08/01 00:01 [medline]
PHST- 1977/08/01 00:00 [entrez]
AID - 10.1152/jappl.1977.43.2.365 [doi]
PST - ppublish
SO  - J Appl Physiol Respir Environ Exerc Physiol. 1977 Aug;43(2):365-9. doi: 
      10.1152/jappl.1977.43.2.365.