PMID- 8937100
OWN - NLM
STAT- MEDLINE
DCOM- 19961224
LR  - 20151008
IS  - 0029-0203 (Print)
IS  - 0029-0203 (Linking)
VI  - 100
IP  - 10
DP  - 1996 Oct
TI  - [The effect of calcium antagonist on ischemia-reperfusion injury of the rabbit 
      retina].
PG  - 773-6
AB  - We investigated the effect of nicardipine (NC), a calcium antagonist, on retinal 
      ischemia-reperfusion injury. Electroretinogram (ERG) was recorded from rabbit 
      eyes before and after ischemia produced by increasing intraocular pressure to 140 
      mmHg for 90 min after giving 0.01% NC (0.1 ml) intravitreally (n = 4). ERGs from 
      intact (non-ischemic) rabbit eyes after injecting NC intravitreally was also 
      recorded (n = 4) (NC group). The recovery rate of b-wave amplitude after 
      reperfusion was significantly higher in the NC group than in the control group 
      which was given saline without NC (p < 0.05). There were no significant 
      differences between the NC and the control groups in a-wave amplitude and 
      implicit time of the b-wave. No significant changes were detected in the a-wave 
      or b-wave amplitude after intravitreal injection of NC into the intact eyes. We 
      suggest that NC can prevent ischemia-reperfusion injury of the rabbit retina and 
      could be considered for clinical use.
FAU - Mori, T
AU  - Mori T
AD  - Department of Ophtkalmology, Iwate Prefectural Central Hospital, Japan.
FAU - Sugawara, T
AU  - Sugawara T
FAU - Hosobe, Y
AU  - Hosobe Y
FAU - Gotoh, T
AU  - Gotoh T
FAU - Kato, C
AU  - Kato C
FAU - Tazawa, Y
AU  - Tazawa Y
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nippon Ganka Gakkai Zasshi
JT  - Nippon Ganka Gakkai zasshi
JID - 7505716
RN  - 0 (Calcium Channel Blockers)
RN  - CZ5312222S (Nicardipine)
SB  - IM
MH  - Animals
MH  - Calcium Channel Blockers/*therapeutic use
MH  - Electroretinography
MH  - Ischemia/*drug therapy/physiopathology
MH  - Nicardipine/*therapeutic use
MH  - Rabbits
MH  - Reperfusion Injury/*drug therapy/physiopathology
MH  - Retinal Diseases/drug therapy/physiopathology
MH  - *Retinal Vessels
EDAT- 1996/10/01 00:00
MHDA- 1996/10/01 00:01
CRDT- 1996/10/01 00:00
PHST- 1996/10/01 00:00 [pubmed]
PHST- 1996/10/01 00:01 [medline]
PHST- 1996/10/01 00:00 [entrez]
PST - ppublish
SO  - Nippon Ganka Gakkai Zasshi. 1996 Oct;100(10):773-6.