PMID- 8937542
OWN - NLM
STAT- MEDLINE
DCOM- 19970303
LR  - 20190814
IS  - 0001-6314 (Print)
IS  - 0001-6314 (Linking)
VI  - 94
IP  - 4
DP  - 1996 Oct
TI  - Intrathecal humoral immune response in HAM/TSP in relation to HLA haplotype 
      analysis.
PG  - 287-93
AB  - INTRODUCTION: In HTLV-1 associated myelopathy/tropical spastic paraparesis 
      (HAM/TSP), we correlated human leukocyte antigen (HLA) haplotypes to the fine 
      specificities of intrathecally synthesized IgG antibodies against HTLV-1. 
      PATIENTS AND METHODS: HLA haplotypes of HAM/TSP patients were determined by the 
      standard NIH microcytotoxicity test and family HLA studies. IgG antibodies 
      against HTLV-1 synthetic peptides in paired CSF and serum were measured by enzyme 
      immunoassay, and intrathecal synthesis of antibodies was evaluated. RESULTS: 
      HAM/TSP patients with particular HLA haplotypes (A24Cw7B7DR1DQ5, A2Cw7B7DR1DQ5, 
      A24Cw-B52DR15DQ6, A11Cw1B54DR4DQ4, and A24Cw1B54DR4DQ4) showed more frequently 
      intrathecal synthesis of antibodies against HTLV-1 synthetic peptides, especially 
      against HTLV-1 env gp21 synthetic peptides. CONCLUSION: In HAM/TSP, a 
      retrovirus-induced human chronic inflammatory disease of the CNS, this is the 
      first report to provide evidence that the intrathecal antiviral immune response 
      is influenced by immunogenetic factors of the HLA complex.
FAU - Kitze, B
AU  - Kitze B
AD  - Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, 
      Japan.
FAU - Usuku, K
AU  - Usuku K
FAU - Yashiki, S
AU  - Yashiki S
FAU - Ijichi, S
AU  - Ijichi S
FAU - Fujiyoshi, T
AU  - Fujiyoshi T
FAU - Nakamura, M
AU  - Nakamura M
FAU - Izumo, S
AU  - Izumo S
FAU - Osame, M
AU  - Osame M
FAU - Sonoda, S
AU  - Sonoda S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Acta Neurol Scand
JT  - Acta neurologica Scandinavica
JID - 0370336
RN  - 0 (HLA Antigens)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - *Antibody Formation
MH  - *HLA Antigens
MH  - HTLV-I Infections/*complications/immunology
MH  - *Haplotypes
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Immunoglobulin G/immunology
MH  - Molecular Sequence Data
MH  - Paraparesis, Tropical Spastic/*etiology/*immunology
EDAT- 1996/10/01 00:00
MHDA- 1996/10/01 00:01
CRDT- 1996/10/01 00:00
PHST- 1996/10/01 00:00 [pubmed]
PHST- 1996/10/01 00:01 [medline]
PHST- 1996/10/01 00:00 [entrez]
AID - 10.1111/j.1600-0404.1996.tb07067.x [doi]
PST - ppublish
SO  - Acta Neurol Scand. 1996 Oct;94(4):287-93. doi: 
      10.1111/j.1600-0404.1996.tb07067.x.