PMID- 8938448
OWN - NLM
STAT- MEDLINE
DCOM- 19970327
LR  - 20091119
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 37
IP  - 3
DP  - 1996 Nov 1
TI  - Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of 
      proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe d'Etude des 
      Neoplasies Endocriniennes Multiples de type 1).
PG  - 354-65
AB  - Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder with 
      a high penetrance characterized by tumors of the parathyroid glands, the 
      endocrine pancreas, and the anterior pituitary. The MEN1 gene, a putative tumor 
      suppressor gene, has been mapped to a 3- to 8-cM region in chromosome 11q13 but 
      it remains elusive as yet. We have combined the efforts and resources from four 
      laboratories to form the European Consortium on MEN1 with the aims of 
      establishing the genetic and the physical maps of 11q13 and of further narrowing 
      the MEN1 region. A 5-Mb integrated map of the region was established by 
      fluorescence in situ hybridization on both metaphase chromosomes and DNA fibers, 
      by hybridization to DNA from somatic cell hybrids containing various parts of 
      human chromosome 11, by long-range restriction mapping, and by characterization 
      of YACs and cosmids. Polymorphic markers were positioned and ordered by physical 
      mapping and genetic linkage in 86 MEN1 families with 452 affected individuals. 
      Two critical recombinants identified in two affected cases placed the MEN1 gene 
      in an approximately 2-Mb region around PYGM, flanked by D11S1883 and D11S449.
FAU - Courseaux, A
AU  - Courseaux A
AD  - LGMCH, CNRS URA 1462, Nice, France. courseaux@unice.fr
FAU - Grosgeorge, J
AU  - Grosgeorge J
FAU - Gaudray, P
AU  - Gaudray P
FAU - Pannett, A A
AU  - Pannett AA
FAU - Forbes, S A
AU  - Forbes SA
FAU - Williamson, C
AU  - Williamson C
FAU - Bassett, D
AU  - Bassett D
FAU - Thakker, R V
AU  - Thakker RV
FAU - Teh, B T
AU  - Teh BT
FAU - Farnebo, F
AU  - Farnebo F
FAU - Shepherd, J
AU  - Shepherd J
FAU - Skogseid, B
AU  - Skogseid B
FAU - Larsson, C
AU  - Larsson C
FAU - Giraud, S
AU  - Giraud S
FAU - Zhang, C X
AU  - Zhang CX
FAU - Salandre, J
AU  - Salandre J
FAU - Calender, A
AU  - Calender A
LA  - eng
SI  - GENBANK/J03569
SI  - GENBANK/J04823
SI  - GENBANK/M11146
SI  - GENBANK/M32579
SI  - GENBANK/M32580
SI  - GENBANK/M32581
SI  - GENBANK/M32582
SI  - GENBANK/M32583
SI  - GENBANK/M32584
SI  - GENBANK/M32585
SI  - GENBANK/M32586
SI  - GENBANK/M32587
SI  - GENBANK/M32588
SI  - GENBANK/M32589
SI  - GENBANK/M32590
SI  - GENBANK/M32591
SI  - GENBANK/M32592
SI  - GENBANK/M32593
SI  - GENBANK/M32594
SI  - GENBANK/M32595
SI  - GENBANK/M32596
SI  - GENBANK/M32597
SI  - GENBANK/M32598
SI  - GENBANK/M32599
SI  - GENBANK/M32600
SI  - GENBANK/M65128
SI  - GENBANK/M80902
SI  - GENBANK/M91003
SI  - GENBANK/X59875
SI  - GENBANK/Z26649
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
SB  - IM
MH  - Animals
MH  - Chromosome Inversion
MH  - Chromosome Mapping
MH  - Chromosomes, Artificial, Yeast/genetics
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - Cosmids/genetics
MH  - Crossing Over, Genetic
MH  - Electrophoresis, Gel, Pulsed-Field
MH  - *Genes, Tumor Suppressor
MH  - Humans
MH  - Hybrid Cells
MH  - In Situ Hybridization, Fluorescence
MH  - Mice
MH  - Molecular Sequence Data
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
EDAT- 1996/11/01 00:00
MHDA- 1996/11/01 00:01
CRDT- 1996/11/01 00:00
PHST- 1996/11/01 00:00 [pubmed]
PHST- 1996/11/01 00:01 [medline]
PHST- 1996/11/01 00:00 [entrez]
PST - ppublish
SO  - Genomics. 1996 Nov 1;37(3):354-65.