PMID- 8938886
OWN - NLM
STAT- MEDLINE
DCOM- 19970226
LR  - 20141120
IS  - 0300-0729 (Print)
IS  - 0300-0729 (Linking)
VI  - 34
IP  - 3
DP  - 1996 Sep
TI  - The association between human leukocyte antigens (HLA) and 
      cytoplasmic-antineutrophil cytoplasmic antibody (cANCA)-positive Wegener's 
      granulomatosis in a Japanese population.
PG  - 163-5
AB  - The present study examined the association between various human leukocyte 
      antigens (HLA) and cytoplasmic-antineutrophil cytoplasmic antibody 
      (cANCA)-positive Wegener's granulomatosis (WG) in Japanese subjects to determine 
      whether HLA antigens are involved in the pathogenesis of this disease. The study 
      involved 16 subjects with cANCA-positive WG treated in our department. HLA-typing 
      of the lymphocytes was performed using a lymphocyte microcytotoxicity assay. Of 
      the subjects with cANCA-positive WG, 62.5% (10/16) were positive for HLA-DR9, as 
      compared to 26% of the healthy control subjects. This HLA-DR9 elevation was 
      statistically significant (p < 0.01, Pc < 0.05); we also noted a weaker 
      association between HLA-B55 and cANCA-positive WG (p < 0.05). The results 
      indicate that an association may exist between certain HLA-class allotypes and 
      WG.
FAU - Nakamaru, Y
AU  - Nakamaru Y
AD  - Department of Otolaryngology, Hokkaido University School of Medicine, Sapporo, 
      Japan.
FAU - Maguchi, S
AU  - Maguchi S
FAU - Takizawa, M
AU  - Takizawa M
FAU - Fukuda, S
AU  - Fukuda S
FAU - Inuyama, Y
AU  - Inuyama Y
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Rhinology
JT  - Rhinology
JID - 0347242
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Antibodies, Antineutrophil Cytoplasmic/*analysis
MH  - Case-Control Studies
MH  - Female
MH  - Granulomatosis with Polyangiitis/genetics/*immunology
MH  - HLA Antigens/*analysis
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 1996/09/01 00:00
MHDA- 1996/09/01 00:01
CRDT- 1996/09/01 00:00
PHST- 1996/09/01 00:00 [pubmed]
PHST- 1996/09/01 00:01 [medline]
PHST- 1996/09/01 00:00 [entrez]
PST - ppublish
SO  - Rhinology. 1996 Sep;34(3):163-5.