PMID- 8939476
OWN - NLM
STAT- MEDLINE
DCOM- 19970314
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 218
IP  - 1
DP  - 1996 Oct 25
TI  - Inhibition of tumor necrosis factor-alpha reduces focal cerebral ischemic injury 
      in the spontaneously hypertensive rat.
PG  - 41-4
AB  - Tumor necrosis factor-alpha (TNF-alpha) is acutely expressed following focal 
      cerebral ischemia, but its pathophysiological role remains to be extensively 
      characterized. In this study we determined the effect of inhibiting TNF-alpha on 
      the microvascular perfusion impairment and ischemic injury induced by permanent 
      middle cerebral artery occlusion (MCAO). TNF-alpha activity was inhibited with 
      recombinant type I soluble TNF receptor (TNFbp; 1 mg/kg i.v., 0.5 h pre- or 
      post-MCAO). TNFbp significantly attenuated the microvessel perfusion impairment 
      observed in vehicle treated rats, particularly in perifocal/penumbral regions of 
      cortex, and significantly reduced (by 34-38%) the total volume of ischemic 
      injury. These results demonstrate that TNF-alpha contributes to focal ischemic 
      injury and that inhibition of TNF-alpha can confer dramatic neuroprotection. The 
      association of the neuroprotective effect of TNFbp with improved microvascular 
      perfusion suggests that inflammatory and vascular responses to TNF-alpha 
      contribute to its pathological action.
FAU - Dawson, D A
AU  - Dawson DA
AD  - Stroke Branch, National Institute of Neurological Disorders and Stroke, National 
      Institutes of Health, Bethesda, Maryland 20892, USA.
FAU - Martin, D
AU  - Martin D
FAU - Hallenbeck, J M
AU  - Hallenbeck JM
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Brain Ischemia/*drug therapy
MH  - Hypertension/drug therapy
MH  - Male
MH  - Microcirculation/*drug effects
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Tumor Necrosis Factor-alpha/*pharmacology
EDAT- 1996/10/25 00:00
MHDA- 1996/10/25 00:01
CRDT- 1996/10/25 00:00
PHST- 1996/10/25 00:00 [pubmed]
PHST- 1996/10/25 00:01 [medline]
PHST- 1996/10/25 00:00 [entrez]
AID - S0304394096131165 [pii]
AID - 10.1016/0304-3940(96)13116-5 [doi]
PST - ppublish
SO  - Neurosci Lett. 1996 Oct 25;218(1):41-4. doi: 10.1016/0304-3940(96)13116-5.