PMID- 8940964
OWN - NLM
STAT- MEDLINE
DCOM- 19961217
LR  - 20190516
IS  - 0002-9637 (Print)
IS  - 0002-9637 (Linking)
VI  - 55
IP  - 5 Suppl
DP  - 1996 Nov
TI  - Immunity and morbidity in infection due to Schistosoma haematobium.
PG  - 116-20
AB  - It has been suggested that immunologic factors, rather than transmission factors, 
      may play a particularly important role in the regulation of schistosome 
      populations. Support for this view comes from several studies of the epidemiology 
      of Schistosoma haematobium infection, although evidence is accumulating from both 
      field and laboratory studies that immunity in schistosomiasis need not be a 
      concomitant immunity. Correlations between immunologic parameters such as 
      peripheral blood eosinophil counts and specific anti-worm immunoglobulin E (IgE) 
      antibody levels, and apparent resistance to reinfection following chemotherapy 
      have been reported and used as evidence in favor of the existence of an acquired 
      immunity. Specific anti-worm IgG4 subclass blocking antibodies have also been 
      described. The relationship between infection intensity and morbidity may not be 
      as simple as has hitherto been assumed, especially since the methods used to 
      generate data on the prevalence and intensity of infection have serious 
      limitations that may only be overcome with improved or alternative sampling 
      techniques.
FAU - Hagan, P
AU  - Hagan P
AD  - Division of Infection and Immunity, University of Glasgow, Scotland, United 
      Kingdom.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
RN  - 0 (Antibodies, Helminth)
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Antibodies, Helminth/biosynthesis
MH  - Gambia/epidemiology
MH  - Humans
MH  - Immunoglobulin E/biosynthesis
MH  - Immunoglobulin G/biosynthesis
MH  - Morbidity
MH  - Prevalence
MH  - Recurrence
MH  - Schistosoma haematobium/*immunology
MH  - Schistosomiasis haematobia/epidemiology/*immunology
MH  - Tanzania/epidemiology
RF  - 31
EDAT- 1996/11/01 00:00
MHDA- 1996/11/01 00:01
CRDT- 1996/11/01 00:00
PHST- 1996/11/01 00:00 [pubmed]
PHST- 1996/11/01 00:01 [medline]
PHST- 1996/11/01 00:00 [entrez]
AID - 10.4269/ajtmh.1996.55.116 [doi]
PST - ppublish
SO  - Am J Trop Med Hyg. 1996 Nov;55(5 Suppl):116-20. doi: 10.4269/ajtmh.1996.55.116.