PMID- 8941525
OWN - NLM
STAT- MEDLINE
DCOM- 19970313
LR  - 20171213
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 81
IP  - 5
DP  - 1996 Nov
TI  - Utilization of glycogen but not plasma glucose is reduced in individuals with 
      NIDDM during mild-intensity exercise.
PG  - 2027-33
AB  - To test the hypothesis that substrate utilization during mild-intensity exercise 
      differs in non-insulin-dependent diabetes mellitus (NIDDM) compared with 
      nondiabetic subjects, seven lean healthy subjects (L), seven obese healthy 
      subjects (O), and seven individuals with NIDDM were studied during 40 min of 
      mild-intensity cycling (40% of peak O2 uptake). Systemic utilization of plasma 
      glucose (Glc Rd) was determined by using isotope dilution methods. Gas exchange 
      was measured to determine rates of carbohydrate (CHO) and lipid oxidation. During 
      exercise, when CHO oxidation was greater than Glc Rd, the net oxidation of 
      glycogen was calculated as the difference: CHO oxidation - Glc Rd. During 
      mild-intensity cycling, the respiratory exchange ratio was similar across groups 
      (0.87 +/- 0.02, 0.85 +/- 0.02, and 0.86 +/- 0.01 in L, O, and NIDDM subjects, 
      respectively), and CHO oxidation accounted for one-half of total energy 
      expenditure during exercise. Glc Rd increased during exercise and was greatest in 
      subjects with NIDDM (3.0 +/- 0.2, 2.9 +/- 0.2, and 4.5 +/- 0.4 ml.kg-1.min-1 in 
      L, O, and NIDDM subjects, respectively, P < 0.05), yet Glc Rd was less than CHO 
      oxidation during exercise, indicating net oxidation of glycogen. Glycogen 
      oxidation was greater in L and O than in NIDDM subjects (3.4 +/- 1.0, 2.5 +/- 
      0.9, and 1.7 +/- 0.8 ml.kg-1.min-1; P < 0.05). In summary, during mild-intensity 
      exercise, NIDDM subjects have an increased Glc Rd and a decreased oxidation of 
      muscle glycogen.
FAU - Colberg, S R
AU  - Colberg SR
AD  - Department of Medicine, University of Pittsburgh School of Medicine, 
      Pennsylvania, USA.
FAU - Hagberg, J M
AU  - Hagberg JM
FAU - McCole, S D
AU  - McCole SD
FAU - Zmuda, J M
AU  - Zmuda JM
FAU - Thompson, P D
AU  - Thompson PD
FAU - Kelley, D E
AU  - Kelley DE
LA  - eng
GR  - 5MO1RR00056/RR/NCRR NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Blood Glucose)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 9005-79-2 (Glycogen)
SB  - IM
MH  - Anaerobic Threshold/physiology
MH  - Blood Glucose/*metabolism
MH  - Body Composition/physiology
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Energy Metabolism/physiology
MH  - Exercise/*physiology
MH  - Fatty Acids, Nonesterified/blood
MH  - Female
MH  - Glycogen/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/metabolism
MH  - Oxidation-Reduction
MH  - Pulmonary Gas Exchange/physiology
EDAT- 1996/11/01 00:00
MHDA- 1996/11/01 00:01
CRDT- 1996/11/01 00:00
PHST- 1996/11/01 00:00 [pubmed]
PHST- 1996/11/01 00:01 [medline]
PHST- 1996/11/01 00:00 [entrez]
AID - 10.1152/jappl.1996.81.5.2027 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 1996 Nov;81(5):2027-33. doi: 10.1152/jappl.1996.81.5.2027.