PMID- 8942447
OWN - NLM
STAT- MEDLINE
DCOM- 19970108
LR  - 20111117
IS  - 0002-953X (Print)
IS  - 0002-953X (Linking)
VI  - 153
IP  - 12
DP  - 1996 Dec
TI  - Genetic association of the HLA DRB1 gene locus on chromosome 6p21.3 with 
      schizophrenia.
PG  - 1530-3
AB  - OBJECTIVE: The authors investigated the human leukocyte antigen (HLA) DRB1*04 
      gene in schizophrenic patients because it is positively associated with 
      rheumatoid arthritis, an autoimmune disease that exhibits a strong negative 
      association with schizophrenia. The HLA DQB1*0602 allele was also studied because 
      of previous reports of genetic association between it and schizophrenia. Maternal 
      HLA was investigated because of the reported association between prenatal 
      influenza and schizophrenia and the central role of HLA molecules in the immune 
      response to viral infections. METHOD: Polymerase chain reactions and 
      sequence-specific oligonucleotide probes were used to genotype 94 unrelated 
      patients with DSM-III-R schizophrenia, 92 mothers of schizophrenic offspring who 
      were not related either to each other or to the 94 patients, and 177 healthy 
      comparison subjects. RESULTS: The frequency of DRB1*04 alleles was significantly 
      lower in both the schizophrenic patients and the unrelated mothers of 
      schizophrenic offspring than in the healthy comparison subjects. No significant 
      differences were found for DQB1*0602. CONCLUSIONS: DRB1*04 alleles may partially 
      account for the genetic predisposition to schizophrenia. The association reported 
      here may be explained by genetic linkage or by an autoimmune pathophysiology for 
      a proportion of schizophrenia cases. Alternatively, it may be that maternal B 
      lymphocytes that do not express the DR4 antigen encoded by DRB1*04 respond to 
      influenza virus by producing antibodies that perturb neurodevelopment, thus 
      underpinning a proportion of schizophrenia cases.
FAU - Wright, P
AU  - Wright P
AD  - Department of Psychological Medicine, Institute of Psychiatry, London, U.K.
FAU - Donaldson, P T
AU  - Donaldson PT
FAU - Underhill, J A
AU  - Underhill JA
FAU - Choudhuri, K
AU  - Choudhuri K
FAU - Doherty, D G
AU  - Doherty DG
FAU - Murray, R M
AU  - Murray RM
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Psychiatry
JT  - The American journal of psychiatry
JID - 0370512
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Chromosomes, Human, Pair 6
MH  - HLA-DQ Antigens
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Schizophrenia/*genetics
EDAT- 1996/12/01 00:00
MHDA- 1996/12/01 00:01
CRDT- 1996/12/01 00:00
PHST- 1996/12/01 00:00 [pubmed]
PHST- 1996/12/01 00:01 [medline]
PHST- 1996/12/01 00:00 [entrez]
AID - 10.1176/ajp.153.12.1530 [doi]
PST - ppublish
SO  - Am J Psychiatry. 1996 Dec;153(12):1530-3. doi: 10.1176/ajp.153.12.1530.