PMID- 8944667
OWN - NLM
STAT- MEDLINE
DCOM- 19970109
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 271
IP  - 5 Pt 1
DP  - 1996 Nov
TI  - Carbohydrate ingestion augments skeletal muscle creatine accumulation during 
      creatine supplementation in humans.
PG  - E821-6
AB  - This study investigated the effect of carbohydrate (CHO) ingestion on skeletal 
      muscle creatine (Cr) accumulation during Cr supplementation in humans. Muscle 
      biopsy, urine, and plasma samples were obtained from 24 males before and after 
      ingesting 5 g Cr in solution (group A) or 5 g Cr followed, 30 min later, by 93 g 
      simple CHO in solution (group B) four times each day for 5 days. Supplementation 
      resulted in an increase in muscle phosphocreatine (PCr), Cr, and total creatine 
      (TCr; sum of PCr and Cr) concentration in groups A and B, but the increase in TCr 
      in group B was 60% greater than in group A (P < 0.01). There was also a 
      corresponding decrease in urinary Cr excretion in group B (P < 0.001). Creatine 
      supplementation had no effect on serum insulin concentration, but Cr and CHO 
      ingestion dramatically elevated insulin concentration (P < 0.001). These findings 
      demonstrate that CHO ingestion substantially augments muscle Cr accumulation 
      during Cr feeding in humans, which appears to be insulin mediated.
FAU - Green, A L
AU  - Green AL
AD  - Department of Physiology and Pharmacology, University Medical School, Queen's 
      Medical Center, Nottingham, United Kingdom.
FAU - Hultman, E
AU  - Hultman E
FAU - Macdonald, I A
AU  - Macdonald IA
FAU - Sewell, D A
AU  - Sewell DA
FAU - Greenhaff, P L
AU  - Greenhaff PL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Dietary Carbohydrates)
RN  - 020IUV4N33 (Phosphocreatine)
RN  - 61D2G4IYVH (Adenosine Diphosphate)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - MU72812GK0 (Creatine)
SB  - IM
MH  - Adenosine Diphosphate/metabolism
MH  - Adenosine Triphosphate/metabolism
MH  - Administration, Oral
MH  - Adult
MH  - Analysis of Variance
MH  - Creatine/administration & dosage/*metabolism/pharmacokinetics
MH  - *Dietary Carbohydrates
MH  - Food, Fortified
MH  - Humans
MH  - Male
MH  - Muscle, Skeletal/*metabolism
MH  - Phosphocreatine/metabolism
MH  - Reference Values
EDAT- 1996/11/01 00:00
MHDA- 1996/11/01 00:01
CRDT- 1996/11/01 00:00
PHST- 1996/11/01 00:00 [pubmed]
PHST- 1996/11/01 00:01 [medline]
PHST- 1996/11/01 00:00 [entrez]
AID - 10.1152/ajpendo.1996.271.5.E821 [doi]
PST - ppublish
SO  - Am J Physiol. 1996 Nov;271(5 Pt 1):E821-6. doi: 10.1152/ajpendo.1996.271.5.E821.