PMID- 8944965
OWN - NLM
STAT- MEDLINE
DCOM- 19970314
LR  - 20190914
IS  - 1058-2916 (Print)
IS  - 1058-2916 (Linking)
VI  - 42
IP  - 5
DP  - 1996 Sep-Oct
TI  - Validation study of a new transit time ultrasonic flow probe for continuous great 
      vessel measurements.
PG  - M671-6
AB  - Continuous measurement of cardiac output is important during experimental and 
      clinical cardiac surgery as an indicator of ventricular function. Previous flow 
      probes underestimated flow secondary to position and flow (S-series probes; 
      Transonic Systems, Inc., Ithaca, NY), required frequent calibrations 
      (electromagnetic), and were cumbersome to use. The new A-series probe (ASP) by 
      Transonic Systems, Inc., uses a new X method of ultrasonic illumination 
      insensitive to perturbations in flow. The ASPs were found to be accurate during 
      in vitro studies, but have not been validated in vivo. Six anesthetized pigs were 
      instrumented for right atrium to left atrium bypass, and ASPs were placed on the 
      ascending aorta and pulmonary artery. Baseline measurements included aortic (Ao) 
      and pulmonic flow (P), and thermodilution (Td) cardiac output. Animals then were 
      placed on right heart bypass, and flow was randomly varied from 1 to 6 L/min, and 
      Ao flow was recorded. In addition, ASPs were rotated and their direction 
      reversed. After data collection, the occlusive roller pump (RP) was calibrated 
      using a timed collection method. Calibrated RP flows were plotted versus ASP 
      flows, and regression was applied. There was no difference between mean Ao, P, 
      and Td cardiac outputs at baseline. In addition, changes in position and 
      direction of the probe did not affect measurement of flow. The ASPs showed a 
      highly linear correlation with RP ([r = 0.98, p < 0.01] ASP[L/min] = 0.98 
      RP-0.032). During laminar flow states, ASPs are accurate and insensitive to 
      position on the great vessels.
FAU - Dean, D A
AU  - Dean DA
AD  - Department of Surgery, Columbia University, College of Physicians and Surgeons, 
      New York, New York 10032, USA.
FAU - Jia, C X
AU  - Jia CX
FAU - Cabreriza, S E
AU  - Cabreriza SE
FAU - D'Alessandro, D A
AU  - D'Alessandro DA
FAU - Dickstein, M L
AU  - Dickstein ML
FAU - Sardo, M J
AU  - Sardo MJ
FAU - Chalik, N
AU  - Chalik N
FAU - Spotnitz, H M
AU  - Spotnitz HM
LA  - eng
GR  - 1 RO1 HL-48109/HL/NHLBI NIH HHS/United States
GR  - HL09325-01/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - ASAIO J
JT  - ASAIO journal (American Society for Artificial Internal Organs : 1992)
JID - 9204109
SB  - IM
MH  - Animals
MH  - Biomedical Engineering
MH  - *Cardiac Output
MH  - Cardiopulmonary Bypass
MH  - Coronary Circulation
MH  - Heart Function Tests/*instrumentation/statistics & numerical data
MH  - Monitoring, Physiologic/instrumentation/statistics & numerical data
MH  - Reproducibility of Results
MH  - Swine
MH  - Ventricular Function
EDAT- 1996/09/01 00:00
MHDA- 1996/09/01 00:01
CRDT- 1996/09/01 00:00
PHST- 1996/09/01 00:00 [pubmed]
PHST- 1996/09/01 00:01 [medline]
PHST- 1996/09/01 00:00 [entrez]
AID - 10.1097/00002480-199609000-00072 [doi]
PST - ppublish
SO  - ASAIO J. 1996 Sep-Oct;42(5):M671-6. doi: 10.1097/00002480-199609000-00072.