PMID- 8946193
OWN - NLM
STAT- MEDLINE
DCOM- 19970303
LR  - 20090929
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 17
IP  - 3
DP  - 1996 Nov
TI  - Localization of a novel t(1;7) translocation associated with Wilms' tumor 
      predisposition and skeletal abnormalities.
PG  - 151-5
AB  - Cytogenetic analysis of predisposition syndromes has played a critical role in 
      the elucidation of the genetics of Wilms' tumor (WT). Therefore, we became 
      interested in a patient who presented with a WT and a nephrogenic rest in the 
      contralateral kidney (suggestive of a predisposition) and a de novo 
      t(1;7)(q42;p15) constitutional translocation as the only visible cytogenetic 
      abnormality. He also had bilateral radial aplasia and other skeletal 
      abnormalities, but there was no manifestation of any syndrome previously 
      associated with WT. In the tumor, the translocation was retained, and the other 
      7p region was lost by the formation of an isochromosome i(7q). Here, we report 
      the localization of the chromosome 7 breakpoint within a yeast artificial 
      chromosome (YAC) contig by using fluorescence in situ hybridization (FISH), 
      localizing the breakpoint between markers sWSS355 and sWSS1449. A number of YACs 
      span the breakpoint and, thus, contain the region that is disrupted by the 
      translocation. This may represent the site of a novel tumor suppressor gene that 
      is involved in WT and also in normal renal development.
FAU - Reynolds, P A
AU  - Reynolds PA
AD  - Department of Pathology and Microbiology, School of Medical Sciences, Bristol, 
      United Kingdom.
FAU - Powlesland, R M
AU  - Powlesland RM
FAU - Keen, T J
AU  - Keen TJ
FAU - Inglehearn, C F
AU  - Inglehearn CF
FAU - Cunningham, A F
AU  - Cunningham AF
FAU - Green, E D
AU  - Green ED
FAU - Brown, K W
AU  - Brown KW
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
SB  - IM
MH  - Bone and Bones/*abnormalities
MH  - Chromosomes, Artificial, Yeast
MH  - *Chromosomes, Human, Pair 7
MH  - Genes, Wilms Tumor/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Kidney/chemistry
MH  - Kidney Neoplasms/*genetics
MH  - Male
MH  - *Translocation, Genetic
MH  - Wilms Tumor/*genetics
EDAT- 1996/11/01 00:00
MHDA- 2000/06/20 09:00
CRDT- 1996/11/01 00:00
PHST- 1996/11/01 00:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1996/11/01 00:00 [entrez]
AID - 10.1002/(SICI)1098-2264(199611)17:3<151::AID-GCC2>3.0.CO;2-3 [pii]
AID - 10.1002/(SICI)1098-2264(199611)17:3<151::AID-GCC2>3.0.CO;2-3 [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 1996 Nov;17(3):151-5. doi: 
      10.1002/(SICI)1098-2264(199611)17:3<151::AID-GCC2>3.0.CO;2-3.