PMID- 8947579
OWN - NLM
STAT- MEDLINE
DCOM- 19961226
LR  - 20220408
IS  - 0145-2126 (Print)
IS  - 0145-2126 (Linking)
VI  - 20
IP  - 9
DP  - 1996 Sep
TI  - Hidden monosomy 7 in acute myeloid leukemia and myelodysplastic syndrome detected 
      by interphase fluorescence in situ hybridization.
PG  - 709-16
AB  - Fifty patients [25 acute myeloid leukemia (AML) and 25 myelodysplastic syndrome 
      (MDS)], without monosomy 7 according to conventional cytogenetics, were 
      re-examined by fluorescence in situ hybridization (FISH). Eleven (44.0%) patients 
      with AML and nine (36.0%) with MDS showed hidden monosomy 7. Two samples who had 
      both monosomy 7 and iso chromosome 17 were analyzed by dual color FISH to 
      identify their clonal origin, and showed that these two abnormalities can occur 
      together or independently. Only one of 16 MDS patients without monosomy 7 
      transformed into AML whereas four of eight MDS patients with the hidden monosomy 
      7 transformed into AML, suggesting patients with this abnormality are more likely 
      to undergo transformation to AML.
FAU - Arif, M
AU  - Arif M
AD  - Department of Cancer Cytogenetics, Hiroshima University, Japan.
FAU - Tanaka, K
AU  - Tanaka K
FAU - Damodaran, C
AU  - Damodaran C
FAU - Asou, H
AU  - Asou H
FAU - Kyo, T
AU  - Kyo T
FAU - Dohy, H
AU  - Dohy H
FAU - Kamada, N
AU  - Kamada N
LA  - eng
PT  - Journal Article
PL  - England
TA  - Leuk Res
JT  - Leukemia research
JID - 7706787
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anemia, Refractory, with Excess of Blasts/*genetics
MH  - Chromosome Banding
MH  - Chromosomes, Human, Pair 17/genetics
MH  - Chromosomes, Human, Pair 7/*genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Myeloid, Acute/*genetics
MH  - Male
MH  - Middle Aged
MH  - Monosomy/*genetics
EDAT- 1996/09/01 00:00
MHDA- 1996/09/01 00:01
CRDT- 1996/09/01 00:00
PHST- 1996/09/01 00:00 [pubmed]
PHST- 1996/09/01 00:01 [medline]
PHST- 1996/09/01 00:00 [entrez]
AID - 0145-2126(96)00018-5 [pii]
AID - 10.1016/0145-2126(96)00018-5 [doi]
PST - ppublish
SO  - Leuk Res. 1996 Sep;20(9):709-16. doi: 10.1016/0145-2126(96)00018-5.