PMID- 8947966
OWN - NLM
STAT- MEDLINE
DCOM- 19970307
LR  - 20181130
IS  - 0031-3998 (Print)
IS  - 0031-3998 (Linking)
VI  - 40
IP  - 6
DP  - 1996 Dec
TI  - Platelet-surface glycoproteins in healthy and preeclamptic mothers and their 
      newborn infants.
PG  - 876-80
AB  - Preeclampsia, a common complication of pregnancy, contributes significantly to 
      maternal and fetal morbidity and mortality. It may lead to both quantitative and 
      qualitative defects of maternal and neonatal platelets. In this prospective 
      study, flow cytometry has been used to study expression of platelet-surface 
      glycoproteins (GPs) on maternal and neonatal platelets of both healthy and 
      preeclamptic subjects. We studied 15 preeclamptic women, 20-44 y of age, and 
      their newborns (median gestational age, 32 wk; range, 26-38) and seven healthy 
      women (aged 26-41 y) and their healthy newborns (median gestational age, 38 wk; 
      range, 38-42). Compared with their healthy and preeclamptic mothers, resting 
      platelets from neonates expressed significantly less CD41 and CD9. Thrombin 
      activation resulted in significant increases in platelet-surface expression of 
      CD62P, CD63, CD41, CD9, and CD36 in neonates and their healthy mothers. Compared 
      with neonates of healthy mothers, platelets from neonates of preeclamptic mothers 
      expressed lower levels of CD62P, CD63, CD9, and CD36 on activated platelets. 
      These findings suggest that preeclampsia influences the expression of 
      platelet-surface GPs on neonatal and maternal platelets, which may affect 
      platelet function, leading to an additional risk for bleeding in thrombocytopenic 
      neonates of mothers with preeclampsia.
FAU - Kuhne, T
AU  - Kuhne T
AD  - Division of Hematology, St Michael's Hospital, Toronto, Ontario, Canada.
FAU - Ryan, G
AU  - Ryan G
FAU - Blanchette, V
AU  - Blanchette V
FAU - Semple, J W
AU  - Semple JW
FAU - Hornstein, A
AU  - Hornstein A
FAU - Mody, M
AU  - Mody M
FAU - Chang, W
AU  - Chang W
FAU - McWhirter, L
AU  - McWhirter L
FAU - Freedman, J
AU  - Freedman J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pediatr Res
JT  - Pediatric research
JID - 0100714
RN  - 0 (Antigens, CD)
RN  - 0 (CD36 Antigens)
RN  - 0 (CD63 protein, human)
RN  - 0 (CD9 protein, human)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (P-Selectin)
RN  - 0 (Platelet Glycoprotein GPIIb-IIIa Complex)
RN  - 0 (Platelet Membrane Glycoproteins)
RN  - 0 (Tetraspanin 29)
RN  - 0 (Tetraspanin 30)
SB  - IM
MH  - Adult
MH  - Antigens, CD/analysis/*blood
MH  - Blood Platelets/chemistry/cytology
MH  - CD36 Antigens/blood
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Infant, Newborn/*blood
MH  - Infant, Premature
MH  - Male
MH  - *Membrane Glycoproteins
MH  - P-Selectin/blood
MH  - Platelet Glycoprotein GPIIb-IIIa Complex/analysis
MH  - Platelet Membrane Glycoproteins/*analysis
MH  - Pre-Eclampsia/*blood
MH  - Pregnancy/*blood
MH  - Reference Values
MH  - Tetraspanin 29
MH  - Tetraspanin 30
EDAT- 1996/12/01 00:00
MHDA- 1996/12/01 00:01
CRDT- 1996/12/01 00:00
PHST- 1996/12/01 00:00 [pubmed]
PHST- 1996/12/01 00:01 [medline]
PHST- 1996/12/01 00:00 [entrez]
AID - 10.1203/00006450-199612000-00018 [doi]
PST - ppublish
SO  - Pediatr Res. 1996 Dec;40(6):876-80. doi: 10.1203/00006450-199612000-00018.